Shifts in mycobacterial populations and emerging drug-resistance in west and central Africa

Florian Gehre; Mebrat Ejo; Kristina Fissette; P De Rijk; Cécile Uwizeye; Elie Nduwamahoro; Odin Goovaerts; Dissou Affolabi; Martin Gninafon; Fanny M Lingoupou; Mamadou Dian Barry; Oumou Sow; Corinne Merle; Piero Olliaro; Fatoumata Ba; Marie Sarr; Alberto Piubello; Juergen Noeske; Martin Antonio; Leen Rigouts; Bouke de Jong

doi:10.1371/journal.pone.0110393

Shifts in mycobacterial populations and emerging drug-resistance in west and central Africa

Florian Gehre, Mebrat Ejo, Kristina Fissette, P De Rijk, Cécile Uwizeye, Elie Nduwamahoro, Odin Goovaerts, Dissou Affolabi, Martin Gninafon, Fanny M Lingoupou, Mamadou Dian Barry, Oumou Sow, Corinne Merle, Piero Olliaro, Fatoumata Ba, Marie Sarr, Alberto Piubello, Juergen Noeske, Martin Antonio, Leen RigoutsBouke de Jong

Mycobacteriology

Research output: Contribution to journal › A1: Web of Science-article › peer-review

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Abstract

In this study, we retrospectively analysed a total of 605 clinical isolates from six West or Central African countries (Benin, Cameroon, Central African Republic, Guinea-Conakry, Niger and Senegal). Besides spoligotyping to assign isolates to ancient and modern mycobacterial lineages, we conducted phenotypic drug-susceptibility-testing for each isolate for the four first-line drugs. We showed that phylogenetically modern Mycobacterium tuberculosis strains are more likely associated with drug resistance than ancient strains and predict that the currently ongoing replacement of the endemic ancient by a modern mycobacterial population in West/Central Africa might result in increased drug resistance in the sub-region.

Original language	English
Journal	PLoS ONE
Volume	9
Issue number	12
Pages (from-to)	e110393
ISSN	1932-6203
DOIs	https://doi.org/10.1371/journal.pone.0110393
Publication status	Published - 2014

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Gehre, F., Ejo, M., Fissette, K., De Rijk, P., Uwizeye, C., Nduwamahoro, E., Goovaerts, O., Affolabi, D., Gninafon, M., Lingoupou, F. M., Barry, M. D., Sow, O., Merle, C., Olliaro, P., Ba, F., Sarr, M., Piubello, A., Noeske, J., Antonio, M., ... de Jong, B. (2014). Shifts in mycobacterial populations and emerging drug-resistance in west and central Africa. PLoS ONE, 9(12), e110393. https://doi.org/10.1371/journal.pone.0110393

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abstract = "In this study, we retrospectively analysed a total of 605 clinical isolates from six West or Central African countries (Benin, Cameroon, Central African Republic, Guinea-Conakry, Niger and Senegal). Besides spoligotyping to assign isolates to ancient and modern mycobacterial lineages, we conducted phenotypic drug-susceptibility-testing for each isolate for the four first-line drugs. We showed that phylogenetically modern Mycobacterium tuberculosis strains are more likely associated with drug resistance than ancient strains and predict that the currently ongoing replacement of the endemic ancient by a modern mycobacterial population in West/Central Africa might result in increased drug resistance in the sub-region.",

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Gehre, F, Ejo, M, Fissette, K, De Rijk, P , Uwizeye, C, Nduwamahoro, E, Goovaerts, O, Affolabi, D, Gninafon, M, Lingoupou, FM, Barry, MD, Sow, O, Merle, C, Olliaro, P, Ba, F, Sarr, M, Piubello, A, Noeske, J, Antonio, M, Rigouts, L & de Jong, B 2014, 'Shifts in mycobacterial populations and emerging drug-resistance in west and central Africa', PLoS ONE, vol. 9, no. 12, pp. e110393. https://doi.org/10.1371/journal.pone.0110393

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T1 - Shifts in mycobacterial populations and emerging drug-resistance in west and central Africa

AU - Gehre, Florian

AU - Ejo, Mebrat

AU - Fissette, Kristina

AU - De Rijk, P

AU - Uwizeye, Cécile

AU - Nduwamahoro, Elie

AU - Goovaerts, Odin

AU - Affolabi, Dissou

AU - Gninafon, Martin

AU - Lingoupou, Fanny M

AU - Barry, Mamadou Dian

AU - Sow, Oumou

AU - Merle, Corinne

AU - Olliaro, Piero

AU - Ba, Fatoumata

AU - Sarr, Marie

AU - Piubello, Alberto

AU - Noeske, Juergen

AU - Antonio, Martin

AU - Rigouts, Leen

AU - de Jong, Bouke

N1 - FTX

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N2 - In this study, we retrospectively analysed a total of 605 clinical isolates from six West or Central African countries (Benin, Cameroon, Central African Republic, Guinea-Conakry, Niger and Senegal). Besides spoligotyping to assign isolates to ancient and modern mycobacterial lineages, we conducted phenotypic drug-susceptibility-testing for each isolate for the four first-line drugs. We showed that phylogenetically modern Mycobacterium tuberculosis strains are more likely associated with drug resistance than ancient strains and predict that the currently ongoing replacement of the endemic ancient by a modern mycobacterial population in West/Central Africa might result in increased drug resistance in the sub-region.

AB - In this study, we retrospectively analysed a total of 605 clinical isolates from six West or Central African countries (Benin, Cameroon, Central African Republic, Guinea-Conakry, Niger and Senegal). Besides spoligotyping to assign isolates to ancient and modern mycobacterial lineages, we conducted phenotypic drug-susceptibility-testing for each isolate for the four first-line drugs. We showed that phylogenetically modern Mycobacterium tuberculosis strains are more likely associated with drug resistance than ancient strains and predict that the currently ongoing replacement of the endemic ancient by a modern mycobacterial population in West/Central Africa might result in increased drug resistance in the sub-region.

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DO - 10.1371/journal.pone.0110393

M3 - A1: Web of Science-article

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VL - 9

SP - e110393

JO - PLoS ONE

JF - PLoS ONE

IS - 12

ER -

Shifts in mycobacterial populations and emerging drug-resistance in west and central Africa

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