Significant rates of risky sexual behaviours among HIV-infected patients failing first-line ART: a sub-study of the Europe-Africa Research Network for the Evaluation of Second-line Therapy trial

Jane N. Wanyama, Maria S. Nabaggala, Bonnie Wandera, Agnes N. Kiragga, Barbara Castelnuovo, Ivan K. Mambule, Josephine Nakajubi, Andrew D. Kambugu, Nicholas I. Paton, Rhoda K. Wanyenze, Robert Colebunders, Philippa Easterbrook

    Research output: Contribution to journalA1: Web of Science-article

    Abstract

    There are limited data on the prevalence of risky sexual behaviours in individuals failing first-line antiretroviral therapy (ART) and changes in sexual behaviour after switch to second-line ART. We undertook a sexual behaviour sub-study of Ugandan adults enrolled in the Europe-Africa Research Network for the Evaluation of Second-line Therapy trial. A standardized questionnaire was used to collect sexual behaviour data and, in particular, risky sexual behaviours (defined as additional sexual partners to main sexual partner, inconsistent use of condoms, non-disclosure to sexual partners, and exchange of money for sex). Of the 79 participants enrolled in the sub-study, 62% were female, median age (IQR) was 37 (32-42) years, median CD4 cell count (IQR) was 79 (50-153) cells/mu l, and median HIV viral load log was 4.9 copies/ml (IQR: 4.5-5.3) at enrolment. The majority were in long-term stable relationships; 69.6% had a main sexual partner and 87.3% of these had been sexually active in the preceding six months. At enrolment, around 20% reported other sexual partners, but this was higher among men than women (36% versus 6.7 %, p

    Original languageEnglish
    JournalInternational Journal of STD & AIDS
    Volume29
    Issue number3
    Pages (from-to)287-297
    Number of pages11
    ISSN0956-4624
    DOIs
    Publication statusPublished - 2018

    Keywords

    • Africa
    • antiretroviral therapy
    • high-risk behaviour
    • HIV
    • sexual behaviour
    • ANTIRETROVIRAL THERAPY
    • SOUTH-AFRICA
    • RURAL UGANDA
    • CAPE-TOWN
    • PREVENTION INTERVENTIONS
    • PROSPECTIVE COHORT
    • SAHARAN AFRICA
    • POSITIVE WOMEN
    • URBAN
    • IMPACT

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