Studies of an Ostertagia ostertagi strain suspected to be resistant to benzimidazoles

FHM Borgsteede; S Geerts; R De Deken; V Kumar; J Brandt

doi:10.1016/0304-4017(92)90011-W

Studies of an Ostertagia ostertagi strain suspected to be resistant to benzimidazoles

FHM Borgsteede, S Geerts, R De Deken, V Kumar, J Brandt

Institute of Tropical Medicine

Research output: Contribution to journal › A1: Web of Science-article › peer-review

Abstract

Four calves were infected with a susceptible (laboratory) strain of Ostertagia ostertagi and four with a field strain suspected to be resistant to benzimidazoles. After 25 days two calves from each group were treated with 3.5 mg kg−1 fenbendazole. Egg output fell to zero in all treated calves. Treated calves did not harbour worms at slaughter 35 days after infection. Significant differences between the strains were shown for ED50 values for thiabendazole in the egg hatch assay, but not in the tubulin binding assay. It is concluded that benzimidazole resistance in the suspected strain cannot be confirmed.

Original language	English
Journal	Veterinary Parasitology
Volume	41
Issue number	1-2
Pages (from-to)	85-92
Number of pages	8
ISSN	0304-4017
DOIs	https://doi.org/10.1016/0304-4017(92)90011-W
Publication status	Published - 1992

Keywords

B780-tropical-medicine
Helminthology
Experimental
Ostertagia ostertagi
Animal
Drug resistance
Benzimidazoles

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10.1016/0304-4017(92)90011-W

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title = "Studies of an Ostertagia ostertagi strain suspected to be resistant to benzimidazoles",

abstract = "Four calves were infected with a susceptible (laboratory) strain of Ostertagia ostertagi and four with a field strain suspected to be resistant to benzimidazoles. After 25 days two calves from each group were treated with 3.5 mg kg−1 fenbendazole. Egg output fell to zero in all treated calves. Treated calves did not harbour worms at slaughter 35 days after infection. Significant differences between the strains were shown for ED50 values for thiabendazole in the egg hatch assay, but not in the tubulin binding assay. It is concluded that benzimidazole resistance in the suspected strain cannot be confirmed. ",

keywords = "B780-tropical-medicine, Helminthology, Experimental, Ostertagia ostertagi, Animal, Drug resistance, Benzimidazoles",

author = "FHM Borgsteede and S Geerts and \{De Deken\}, R and V Kumar and J Brandt",

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AU - Borgsteede, FHM

AU - Geerts, S

AU - De Deken, R

AU - Kumar, V

AU - Brandt, J

N1 - FTX: Available in ITM print journal collection

PY - 1992

Y1 - 1992

N2 - Four calves were infected with a susceptible (laboratory) strain of Ostertagia ostertagi and four with a field strain suspected to be resistant to benzimidazoles. After 25 days two calves from each group were treated with 3.5 mg kg−1 fenbendazole. Egg output fell to zero in all treated calves. Treated calves did not harbour worms at slaughter 35 days after infection. Significant differences between the strains were shown for ED50 values for thiabendazole in the egg hatch assay, but not in the tubulin binding assay. It is concluded that benzimidazole resistance in the suspected strain cannot be confirmed.

AB - Four calves were infected with a susceptible (laboratory) strain of Ostertagia ostertagi and four with a field strain suspected to be resistant to benzimidazoles. After 25 days two calves from each group were treated with 3.5 mg kg−1 fenbendazole. Egg output fell to zero in all treated calves. Treated calves did not harbour worms at slaughter 35 days after infection. Significant differences between the strains were shown for ED50 values for thiabendazole in the egg hatch assay, but not in the tubulin binding assay. It is concluded that benzimidazole resistance in the suspected strain cannot be confirmed.

KW - B780-tropical-medicine

KW - Helminthology

KW - Experimental

KW - Ostertagia ostertagi

KW - Animal

KW - Drug resistance

KW - Benzimidazoles

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JO - Veterinary Parasitology

JF - Veterinary Parasitology

IS - 1-2

ER -

Studies of an Ostertagia ostertagi strain suspected to be resistant to benzimidazoles

Abstract

Keywords

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