Surface-engineered polyelectrolyte multilayer capsules-synthetic vaccines mimicking microbial structure and function

B.G. De Geest, M.A. Willart, B.N. Lambrecht, C. Pollard, C. Vervaet, J.P. Remon, J. Grooten, S. De Koker

Research output: Contribution to journalA1: Web of Science-article

Abstract

Immunizing: To evoke highly potent immune responses against recombinant antigens, hollow capsules consisting of layers of dextran sulphate and poly-L-arginine that encapsulate the antigen ovalbumin (orange circles) were coated with immune-activating CpG-containing oligonucleotides (green). These capsules were readily internalized by dendritic cells and showed activity in further immunization experiments.
Original languageEnglish
JournalAngewandte Chemie (International Edition in English)
Volume51
Issue number13
Pages (from-to)3862-3866
Number of pages5
ISSN1433-7851
DOIs
Publication statusPublished - 2012

Keywords

  • Viral diseases
  • HIV
  • AIDS
  • Vaccine development
  • Cellular
  • Immune response
  • T cells
  • CD4-positive-T-lymphocytes
  • CD8-positive-T-lymphocytes
  • Antigens
  • Mimicking
  • Polyelectrolyte multilayer capsules
  • Global

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