Surface-engineered polyelectrolyte multilayer capsules-synthetic vaccines mimicking microbial structure and function

B.G. De Geest; M.A. Willart; B.N. Lambrecht; C. Pollard; C. Vervaet; J.P. Remon; J. Grooten; S. De Koker

doi:10.1002/anie.201200048

Surface-engineered polyelectrolyte multilayer capsules-synthetic vaccines mimicking microbial structure and function

B.G. De Geest, M.A. Willart, B.N. Lambrecht, C. Pollard, C. Vervaet, J.P. Remon, J. Grooten, S. De Koker

Virology

Research output: Contribution to journal › A1: Web of Science-article › peer-review

Abstract

Immunizing: To evoke highly potent immune responses against recombinant antigens, hollow capsules consisting of layers of dextran sulphate and poly-L-arginine that encapsulate the antigen ovalbumin (orange circles) were coated with immune-activating CpG-containing oligonucleotides (green). These capsules were readily internalized by dendritic cells and showed activity in further immunization experiments.

Original language	English
Journal	Angewandte Chemie (International Edition in English)
Volume	51
Issue number	13
Pages (from-to)	3862-3866
Number of pages	5
ISSN	1433-7851
DOIs	https://doi.org/10.1002/anie.201200048
Publication status	Published - 2012

Keywords

Viral diseases
HIV
AIDS
Vaccine development
Cellular
Immune response
T cells
CD4-positive-T-lymphocytes
CD8-positive-T-lymphocytes
Antigens
Mimicking
Polyelectrolyte multilayer capsules
Global

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10.1002/anie.201200048

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title = "Surface-engineered polyelectrolyte multilayer capsules-synthetic vaccines mimicking microbial structure and function",

abstract = "Immunizing: To evoke highly potent immune responses against recombinant antigens, hollow capsules consisting of layers of dextran sulphate and poly-L-arginine that encapsulate the antigen ovalbumin (orange circles) were coated with immune-activating CpG-containing oligonucleotides (green). These capsules were readily internalized by dendritic cells and showed activity in further immunization experiments.",

keywords = "Viral diseases, HIV, AIDS, Vaccine development, Cellular, Immune response, T cells, CD4-positive-T-lymphocytes, CD8-positive-T-lymphocytes, Antigens, Mimicking, Polyelectrolyte multilayer capsules, Global",

author = "{De Geest}, B.G. and M.A. Willart and B.N. Lambrecht and C. Pollard and C. Vervaet and J.P. Remon and J. Grooten and {De Koker}, S.",

note = "PPU; ITG-B4B; DBM; U-VIROL; JIF; DOI; PDF; Abstract; DSPACE",

year = "2012",

doi = "10.1002/anie.201200048",

language = "English",

volume = "51",

pages = "3862--3866",

journal = "Angewandte Chemie (International Edition in English)",

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publisher = "John Wiley & Sons",

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T1 - Surface-engineered polyelectrolyte multilayer capsules-synthetic vaccines mimicking microbial structure and function

AU - De Geest, B.G.

AU - Willart, M.A.

AU - Lambrecht, B.N.

AU - Pollard, C.

AU - Vervaet, C.

AU - Remon, J.P.

AU - Grooten, J.

AU - De Koker, S.

N1 - PPU; ITG-B4B; DBM; U-VIROL; JIF; DOI; PDF; Abstract; DSPACE

PY - 2012

Y1 - 2012

N2 - Immunizing: To evoke highly potent immune responses against recombinant antigens, hollow capsules consisting of layers of dextran sulphate and poly-L-arginine that encapsulate the antigen ovalbumin (orange circles) were coated with immune-activating CpG-containing oligonucleotides (green). These capsules were readily internalized by dendritic cells and showed activity in further immunization experiments.

AB - Immunizing: To evoke highly potent immune responses against recombinant antigens, hollow capsules consisting of layers of dextran sulphate and poly-L-arginine that encapsulate the antigen ovalbumin (orange circles) were coated with immune-activating CpG-containing oligonucleotides (green). These capsules were readily internalized by dendritic cells and showed activity in further immunization experiments.

KW - Viral diseases

KW - HIV

KW - AIDS

KW - Vaccine development

KW - Cellular

KW - Immune response

KW - T cells

KW - CD4-positive-T-lymphocytes

KW - CD8-positive-T-lymphocytes

KW - Antigens

KW - Mimicking

KW - Polyelectrolyte multilayer capsules

KW - Global

U2 - 10.1002/anie.201200048

DO - 10.1002/anie.201200048

M3 - A1: Web of Science-article

C2 - 22411781

SN - 1433-7851

VL - 51

SP - 3862

EP - 3866

JO - Angewandte Chemie (International Edition in English)

JF - Angewandte Chemie (International Edition in English)

IS - 13

ER -

Surface-engineered polyelectrolyte multilayer capsules-synthetic vaccines mimicking microbial structure and function

Abstract

Keywords

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