Synthesis, evaluation and structure-activity relationships of triazine dimers as novel antiviral agents

M. Venkatraj, K.K. Ariën, J. Heeres, J. Joossens, J. Messagie, J. Michiels, P. Van der Veken, G. Vanham, P.J. Lewi, K. Augustyns

Research output: Contribution to journalA1: Web of Science-article

Abstract

This letter reports the synthesis and structure-activity relationship (SAR) study of a series of triazine dimers as novel antiviral agents. These compounds were obtained through a bivalent ligand approach in which two triazine moieties are covalently connected by suitable linkers. Several compounds showed submicromolar activity against wild-type HIV-1 and moderate activity against single mutant strains.
Original languageEnglish
JournalBioorganic and Medicinal Chemistry Letters
Volume22
Issue number23
Pages (from-to)7174-7178
Number of pages5
ISSN0960-894X
DOIs
Publication statusPublished - 2012

Keywords

  • Viral diseases
  • HIV-1
  • AIDS
  • Microbicides
  • Development
  • Antiviral agents
  • Triazines
  • Evaluation
  • Cytotoxicity
  • Reverse transcriptase
  • Strains

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