Targeting of human antigen-presenting cell subsets

C. Goyvaerts; J. Dingemans; K. De Groeve; C. Heirman; E. Van Gulck; G. Vanham; P. De Baetselier; K. Thielemans; G. Raes; K. Breckpot

doi:10.1128/JVI.01498-13

Targeting of human antigen-presenting cell subsets

C. Goyvaerts, J. Dingemans, K. De Groeve, C. Heirman, E. Van Gulck, G. Vanham, P. De Baetselier, K. Thielemans, G. Raes, K. Breckpot

Virology

Research output: Contribution to journal › A1: Web of Science-article › peer-review

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Abstract

Antigen-presenting cells are a heterogeneous group of cells that are characterized by their functional specialization. Consequently, targeting specific antigen-presenting cell subsets offers opportunities to induce distinct T cell responses. Here we report on the generation and use of Nanobodies (Nbs) to target lentivectors specifically to human lymph node-resident myeloid dendritic cells, demonstrating that Nbs represent a powerful tool to redirect lentivectors to human antigen-presenting cell subsets.

Original language	English
Journal	Journal of Virology
Volume	87
Issue number	20
Pages (from-to)	11304-11308
Number of pages	5
ISSN	0022-538X
DOIs	https://doi.org/10.1128/JVI.01498-13
Publication status	Published - 2013

Keywords

Viral diseases
Vaccine development
Antigen detection
Dendritic cells
Nanobodies
Lymph nodes
Myeloid cells
Specificity
Macrophages
Flow cytometry

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10.1128/JVI.01498-13

2013jvir11304

http://lib.itg.be/pdf/itg/2013/2013jvir11304.pdf

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title = "Targeting of human antigen-presenting cell subsets",

abstract = "Antigen-presenting cells are a heterogeneous group of cells that are characterized by their functional specialization. Consequently, targeting specific antigen-presenting cell subsets offers opportunities to induce distinct T cell responses. Here we report on the generation and use of Nanobodies (Nbs) to target lentivectors specifically to human lymph node-resident myeloid dendritic cells, demonstrating that Nbs represent a powerful tool to redirect lentivectors to human antigen-presenting cell subsets.",

keywords = "Viral diseases, Vaccine development, Antigen detection, Dendritic cells, Nanobodies, Lymph nodes, Myeloid cells, Specificity, Macrophages, Flow cytometry",

author = "C. Goyvaerts and J. Dingemans and {De Groeve}, K. and C. Heirman and {Van Gulck}, E. and G. Vanham and {De Baetselier}, P. and K. Thielemans and G. Raes and K. Breckpot",

note = "FTX; ITG-B5B; ITG-B6A; DBM; U-VIROL; JIF; DOI; PDF; Abstract; DSPACE56",

year = "2013",

doi = "10.1128/JVI.01498-13",

language = "English",

volume = "87",

pages = "11304--11308",

journal = "Journal of Virology",

issn = "0022-538X",

publisher = "American Society for Microbiology",

number = "20",

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TY - JOUR

T1 - Targeting of human antigen-presenting cell subsets

AU - Goyvaerts, C.

AU - Dingemans, J.

AU - De Groeve, K.

AU - Heirman, C.

AU - Van Gulck, E.

AU - Vanham, G.

AU - De Baetselier, P.

AU - Thielemans, K.

AU - Raes, G.

AU - Breckpot, K.

N1 - FTX; ITG-B5B; ITG-B6A; DBM; U-VIROL; JIF; DOI; PDF; Abstract; DSPACE56

PY - 2013

Y1 - 2013

N2 - Antigen-presenting cells are a heterogeneous group of cells that are characterized by their functional specialization. Consequently, targeting specific antigen-presenting cell subsets offers opportunities to induce distinct T cell responses. Here we report on the generation and use of Nanobodies (Nbs) to target lentivectors specifically to human lymph node-resident myeloid dendritic cells, demonstrating that Nbs represent a powerful tool to redirect lentivectors to human antigen-presenting cell subsets.

AB - Antigen-presenting cells are a heterogeneous group of cells that are characterized by their functional specialization. Consequently, targeting specific antigen-presenting cell subsets offers opportunities to induce distinct T cell responses. Here we report on the generation and use of Nanobodies (Nbs) to target lentivectors specifically to human lymph node-resident myeloid dendritic cells, demonstrating that Nbs represent a powerful tool to redirect lentivectors to human antigen-presenting cell subsets.

KW - Viral diseases

KW - Vaccine development

KW - Antigen detection

KW - Dendritic cells

KW - Nanobodies

KW - Lymph nodes

KW - Myeloid cells

KW - Specificity

KW - Macrophages

KW - Flow cytometry

U2 - 10.1128/JVI.01498-13

DO - 10.1128/JVI.01498-13

M3 - A1: Web of Science-article

C2 - 23864630

SN - 0022-538X

VL - 87

SP - 11304

EP - 11308

JO - Journal of Virology

JF - Journal of Virology

IS - 20

ER -

Targeting of human antigen-presenting cell subsets

Abstract

Keywords

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