Targeting of human antigen-presenting cell subsets

C. Goyvaerts, J. Dingemans, K. De Groeve, C. Heirman, E. Van Gulck, G. Vanham, P. De Baetselier, K. Thielemans, G. Raes, K. Breckpot

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Abstract

Antigen-presenting cells are a heterogeneous group of cells that are characterized by their functional specialization. Consequently, targeting specific antigen-presenting cell subsets offers opportunities to induce distinct T cell responses. Here we report on the generation and use of Nanobodies (Nbs) to target lentivectors specifically to human lymph node-resident myeloid dendritic cells, demonstrating that Nbs represent a powerful tool to redirect lentivectors to human antigen-presenting cell subsets.
Original languageEnglish
JournalJournal of Virology
Volume87
Issue number20
Pages (from-to)11304-11308
Number of pages5
ISSN0022-538X
DOIs
Publication statusPublished - 2013

Keywords

  • Viral diseases
  • Vaccine development
  • Antigen detection
  • Dendritic cells
  • Nanobodies
  • Lymph nodes
  • Myeloid cells
  • Specificity
  • Macrophages
  • Flow cytometry

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