Tenofovir diphosphate and emtricitabine triphosphate concentrations in blood cells compared with isolated peripheral blood mononuclear cells: a new measure of antiretroviral adherence?

J.L. Adams, C. Sykes, P. Menezes, H.M. Prince, K.B. Patterson, K. Fransen, T. Crucitti, Irith De Baetselier, L. Van Damme, A.D. Kashuba

    Research output: Contribution to journalA1: Web of Science-article

    Abstract

    BACKGROUND: The active metabolites of tenofovir (TFV) and emtricitabine (FTC) in peripheral blood mononuclear cells (PBMCs) have been used as markers of long-term antiretroviral (ARV) adherence. However, the process of isolating PBMCs is expensive, complex, and not feasible in many settings. We compared concentrations of TFV-diphosphate (TFV-DP) and FTC-triphosphate (FTC-TP) in the upper layer packed cells (ULPC) obtained after whole blood centrifugation to isolated PBMCs as a possible alternative marker of adherence. METHODS:: Ten HIV+ adults with HIV RNA
    Original languageEnglish
    JournalJournal of Acquired Immune Deficiency Syndromes
    Volume62
    Issue number3
    Pages (from-to)260-266
    Number of pages7
    ISSN1525-4135
    DOIs
    Publication statusPublished - 2013

    Keywords

    • Viral diseases
    • HIV
    • AIDS
    • HAART
    • Antiretrovirals
    • Compliance
    • Peripheral blood mononuclear cell (PBMC)
    • Markers
    • Concentration
    • Tenofovir
    • Emtricitabine
    • Liquid
    • Chromatography
    • Mass spectrometry
    • Correlation
    • Intracellular
    • Blood

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