The association between malaria, blood transfusions, and HIV seropositivity in a pediatric population in Kinshasa, Zaire

AE Greenberg, P Nguyen Dinh, JM Mann, N Kabote, RL Colebunders, H Francis, TC Quinn, P Baudoux, B Lyamba, F Davachi

    Research output: Contribution to journalA1: Web of Science-article

    Abstract

    Since Plasmodium falciparum malaria is a frequent cause of anemia among African children, and blood transfusions, unscreened for human immunodeficiency virus (HIV) antibody, are used frequently in the treatment of children with severe malaria, the relationships between malaria, transfusions, and HIV seropositivity were investigated in a pediatric population in Kinshasa, Zaire. In a cross-sectional survey of 167 hospitalized children, 112 (67%) had malaria, 78 (47%) had received transfusions during the current hospitalization, and 21 (13%) were HIV seropositive. Ten of the 11 seropositive malaria patients had received transfusions during the current hospitalization; pretransfusion specimens were available for four of these children and were seronegative. Of all blood transfusions, 87% were administered to malaria patients, and there was a strong dose-response association between transfusions and HIV seropositivity. A review of 1000 emergency ward records demonstrated that 69% of transfusions were administered to malaria patients, and 97% of children who received transfusions had pretransfusion hematocrits of 0.25 or less (less than or equal to 25%). The treatment of malaria with blood transfusions is an important factor in the exposure of Kinshasa children to HIV infection
    Original languageEnglish
    JournalJournal of the American Medical Association
    Volume259
    Pages (from-to)545-549
    ISSN0098-7484
    Publication statusPublished - 1988

    Keywords

    • B780-tropical-medicine
    • Blood transfusion
    • Adverse effects
    • HIV
    • Viral diseases
    • Seropositivity
    • Complications
    • Malaria
    • Protozoal diseases
    • Treatment
    • Cross sectional studies
    • Infants
    • Plasmodium falciparum
    • Congo-Kinshasa
    • Africa-Central

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