The burden of hospitalizations and clinic visits for rotavirus disease in children aged

Celia C Carlos, Marianette T Inobaya, Joseph S Bresee, Marietta L Lagrada, Agnettah M Olorosa, Carl D Kirkwood, Marc-Alain Widdowson

Research output: Contribution to journalA1: Web of Science-articlepeer-review


BACKGROUND: Recent data on the burden of hospitalization and clinic visits for rotavirus gastroenteritis are needed to support the decision to introduce rotavirus vaccine in the Philippines.

METHODS: From 2005 through 2006, children aged <5 years with acute diarrhea who attended 1 of 7 clinics and/or hospitals in Muntinlupa City, the Philippines, were enrolled. Clinical and demographic data were collected, and a stool specimen was obtained for rotavirus testing and typing for G and P antigens. The incidences of different clinical outcomes of rotavirus gastroenteritis were determined for 3 townships under surveillance and were extrapolated to the Philippines with use of national data sets.

RESULTS: The prevalence of rotavirus was 31% (171/560) among children hospitalized with diarrhea, 30% (155/520) among those who presented to the emergency department, and 15% (56/385) among those who presented to a clinic. The annual estimated incidence (per 100,000 children aged <5 years) of rotavirus gastroenteritis in outpatient, emergency department, and inpatient settings was 755, 451, and 279, respectively. Of 274 strains, 50 (18%) were nontypeable. Of the 128 strains that underwent G and P typing, 98% belong to the globally common strains G3P[P], G2P[4], and G1P[8].

CONCLUSIONS: The burden of rotavirus gastroenteritis in the Philippines is high and is predominantly caused by strains against which current vaccines have shown good efficacy, suggesting that routine immunization will have a large impact on rotavirus disease burden.

Original languageEnglish
JournalJournal of Infectious Diseases
Volume200 Suppl 1
Pages (from-to)S174-S181
Publication statusPublished - 2009


  • Child, Preschool
  • Cost of Illness
  • Gastroenteritis/epidemiology
  • Genotype
  • Hospitalization
  • Humans
  • Incidence
  • Infant
  • Infant, Newborn
  • Philippines/epidemiology
  • Rotavirus/classification
  • Rotavirus Infections/epidemiology


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