The FAS-670 AA genotype is associated with high proviral load in peruvian HAM/TSP patients

Jason Rosado, Sandra Morales, Giovanni López, Daniel Clark, Kristien Verdonck, Eduardo Gotuzzo, Guy Van Camp, Michael Talledo

    Research output: Contribution to journalA1: Web of Science-article

    Abstract

    Human T-lymphotropic virus 1 (HTLV-1) is the etiologic agent of the HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Apoptosis is a mechanism of defense elicited by many triggers, including cross-linking of the FAS receptor expressed in viruses-infected cells, and the ligand FASL presented by T-cytotoxic cells. As HAM/TSP has been associated with high levels of proviral load (PVL), we hypothesized that certain genotypes of single-nucleotide polymorphisms (SNPs) associated with a decreased protein expression of FAS and FASL could be risk factors for this disease. Three SNPs: FAS-670A/G (rs1800682), FAS-1377G/A (rs2234767), and FASL-844C/T (rs763110) were analyzed in 73 HAM/TSP patients and 143 HTLV-1 asymptomatic carriers. Ancestry informative markers were used to adjust for ethnicity through a principal component analysis. Gender, age, PVL, and the first three principal components were used as covariates. The FAS/FASL genotype distribution was not associated with HAM/TSP presence (P-> 0.05). The FAS-670 AA genotype was associated with high PVL in comparison to FAS-670 GG in HAM/TSP patients (P = 0.015), while in asymptomatic carriers low levels of PVL were observed (P > 0.05). Our findings suggest that rs1800682, rs2234767, and rs763110 genotypes are not associated with the presence of HAM/TSP, but that the FAS-670 AA genotype can promote higher PVL values in HAM/TSP patients. J. Med. Virol. 89:726-731, 2017. © 2016 Wiley Periodicals, Inc.

    Original languageEnglish
    JournalJournal of Medical Virology
    Volume89
    Issue number4
    Pages (from-to)726-731
    Number of pages6
    ISSN0146-6615
    DOIs
    Publication statusPublished - 2017

    Keywords

    • Cohort Studies
    • Female
    • Genotype
    • HTLV-I Infections
    • Humans
    • Male
    • Middle Aged
    • Polymorphism, Single Nucleotide
    • Proviruses
    • Viral Load
    • fas Receptor
    • Journal Article

    Fingerprint

    Dive into the research topics of 'The FAS-670 AA genotype is associated with high proviral load in peruvian HAM/TSP patients'. Together they form a unique fingerprint.

    Cite this