The human Mpox global outbreak: available control tools and the opportunity to break a cycle of neglect in endemic countries

Jean B Nachega, Placide Mbala-Kingebeni, Philip J Rosenthal, Anne W Rimoin, Nicole A Hoff, Laurens Liesenborghs, Veerle Vanlerberghe, Graciela Andrei, Angeli Rawat, Lindsay A Wilson, Jamie Forrest, Edward J Mills, Michel P Hermans, Sabue Mulangu, Francine Ntoumi, Alimuddin Zumla, Jean-Jacques Muyembe-Tamfum

Research output: Contribution to journalA1: Web of Science-articlepeer-review


The 2022 global outbreak of human Mpox (formerly monkeypox) virus (MPXV) infection outside of the usual endemic zones in Africa challenged our understanding of the virus's natural history, transmission dynamics, and risk factors. This outbreak has highlighted the need for diagnostics, vaccines, therapeutics, and implementation research, all of which require more substantial investments in equitable collaborative partnerships. Global multidisciplinary networks need to tackle MPXV and other neglected emerging and reemerging zoonotic pathogens to address them locally and prevent or quickly control their worldwide spread. Political endorsement from individual countries and financial commitments to maintain control efforts will be essential for long-term sustainability.

Original languageEnglish
JournalAmerican Journal of Tropical Medicine and Hygiene
Issue number4
Pages (from-to)719-724
Number of pages6
Publication statusPublished - 2023

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