The incidence of human cysticercosis in a rural community of Eastern Zambia

K.E. Mwape, I.K. Phiri, N. Praet, N. Speybroeck, J.B. Muma, P. Dorny, S. Gabriel

    Research output: Contribution to journalA1: Web of Science-articlepeer-review

    21 Downloads (Pure)

    Abstract

    A community-based longitudinal study was performed in the Eastern Province of Zambia, in which repeated serological samplings were done to determine the incidence of human cysticercosis. Three sampling rounds were carried out at six months intervals. A total of 867 participants presented for all three samplings. All samples were tested for the presence of cysticercus antigens using a monoclonal antibody-based enzyme-linked immunosorbent assay (sero-Ag-ELISA), while a randomly selected sub-sample of 161 samples from each sampling round was tested for specific antibodies using a commercial enzyme-linked immunoelectrotransfer blot (EITB) assay. Stool samples (n = 226) were also collected during the final round of sampling for taeniosis diagnosis by coprology and coproantigen ELISA. Cysticercosis seroprevalence varied from 12.2% to 14.5% (sero-Ag) and from 33.5% to 38.5% (sero-Ab) during the study period. A taeniosis prevalence of 11.9% was determined. Incidence rates of 6300 (sero-Ag, per 100000 persons-year) and 23600 (sero-Ab, per 100000 persons-year) were determined. Seroreversion rates of 44% for sero-Ag and 38.7% for sero-Ab were recorded over the whole period. In conclusion, this study has shown the dynamic nature of T. solium infections; many of the people at risk become (re)infected due to the high environmental contamination, with a high number turning seronegative within a year after infection. An important number of infections probably never fully establish, leading to transient antibody responses and short-term antigen presence.
    Original languageEnglish
    JournalPLoS Neglected Tropical Diseases
    Volume7
    Issue number3
    Pages (from-to)e2142
    ISSN1935-2727
    DOIs
    Publication statusPublished - 2013

    Keywords

    • Helminthic diseases
    • Cysticercosis
    • Cysticercus bovis
    • Taenia solium
    • Zoonoses
    • Pigs
    • Humans
    • Incidence
    • Ag-ELISA
    • Enzyme-linked immunoelectrotransfer blot (EITB)
    • Antigens
    • Antibodies
    • Coprology
    • Seroconversion
    • Rural
    • Zambia
    • Africa-Southern

    Fingerprint

    Dive into the research topics of 'The incidence of human cysticercosis in a rural community of Eastern Zambia'. Together they form a unique fingerprint.

    Cite this