The production of nitric oxide and tumor necrosis factor by murine macrophages infected with mycobacterial strains differing by hemolytic activity

W Rudnicka; M Brzychcy; M Klink; AG Lopez; PA Fonteyne; S Rusch-Gerdes; B Rozalska

doi:10.1111/j.1348-0421.1999.tb02451.x

The production of nitric oxide and tumor necrosis factor by murine macrophages infected with mycobacterial strains differing by hemolytic activity

W Rudnicka, M Brzychcy, M Klink, AG Lopez, PA Fonteyne, S Rusch-Gerdes, B Rozalska

Institute of Tropical Medicine

Research output: Contribution to journal › A1: Web of Science-article › peer-review

Abstract

In this study, we compared the secretion of nitric oxide (NO) and tumor necrosis factor (TNF-α) by murine macrophages infected in vitro with hemolytic or unhemolytic mycobacteria isolates. We observed that unhemolytic mycobacteria induced more intensive NO production by macrophages and were more susceptible to bactericidal effect of mononuclear phagocytes than hemolytic mycobacterial strains. In contrast, the high-virulence hemolytic isolates induced significantly stronger TNF-α production by infected macrophages than the low-virulence unhemolytic bacilli.

Original language	English
Journal	Microbiology and Immunology
Volume	43
Issue number	7
Pages (from-to)	637-644
Number of pages	8
DOIs	https://doi.org/10.1111/j.1348-0421.1999.tb02451.x
Publication status	Published - 1999

Keywords

B780-tropical-medicine
Bacteriology
Mycobacteria
Tumor necrosis factor
Nitric oxide

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10.1111/j.1348-0421.1999.tb02451.x

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title = "The production of nitric oxide and tumor necrosis factor by murine macrophages infected with mycobacterial strains differing by hemolytic activity",

abstract = "In this study, we compared the secretion of nitric oxide (NO) and tumor necrosis factor (TNF-α) by murine macrophages infected in vitro with hemolytic or unhemolytic mycobacteria isolates. We observed that unhemolytic mycobacteria induced more intensive NO production by macrophages and were more susceptible to bactericidal effect of mononuclear phagocytes than hemolytic mycobacterial strains. In contrast, the high-virulence hemolytic isolates induced significantly stronger TNF-α production by infected macrophages than the low-virulence unhemolytic bacilli.",

keywords = "B780-tropical-medicine, Bacteriology, Mycobacteria, Tumor necrosis factor, Nitric oxide",

author = "W Rudnicka and M Brzychcy and M Klink and AG Lopez and PA Fonteyne and S Rusch-Gerdes and B Rozalska",

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doi = "10.1111/j.1348-0421.1999.tb02451.x",

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T1 - The production of nitric oxide and tumor necrosis factor by murine macrophages infected with mycobacterial strains differing by hemolytic activity

AU - Rudnicka, W

AU - Brzychcy, M

AU - Klink, M

AU - Lopez, AG

AU - Fonteyne, PA

AU - Rusch-Gerdes, S

AU - Rozalska, B

N1 - FTX: Abonnement

PY - 1999

Y1 - 1999

N2 - In this study, we compared the secretion of nitric oxide (NO) and tumor necrosis factor (TNF-α) by murine macrophages infected in vitro with hemolytic or unhemolytic mycobacteria isolates. We observed that unhemolytic mycobacteria induced more intensive NO production by macrophages and were more susceptible to bactericidal effect of mononuclear phagocytes than hemolytic mycobacterial strains. In contrast, the high-virulence hemolytic isolates induced significantly stronger TNF-α production by infected macrophages than the low-virulence unhemolytic bacilli.

AB - In this study, we compared the secretion of nitric oxide (NO) and tumor necrosis factor (TNF-α) by murine macrophages infected in vitro with hemolytic or unhemolytic mycobacteria isolates. We observed that unhemolytic mycobacteria induced more intensive NO production by macrophages and were more susceptible to bactericidal effect of mononuclear phagocytes than hemolytic mycobacterial strains. In contrast, the high-virulence hemolytic isolates induced significantly stronger TNF-α production by infected macrophages than the low-virulence unhemolytic bacilli.

KW - B780-tropical-medicine

KW - Bacteriology

KW - Mycobacteria

KW - Tumor necrosis factor

KW - Nitric oxide

UR - https://www.webofscience.com/wos/woscc/full-record/WOS:000081243100004

U2 - 10.1111/j.1348-0421.1999.tb02451.x

DO - 10.1111/j.1348-0421.1999.tb02451.x

M3 - A1: Web of Science-article

VL - 43

SP - 637

EP - 644

JO - Microbiology and Immunology

JF - Microbiology and Immunology

IS - 7

ER -

The production of nitric oxide and tumor necrosis factor by murine macrophages infected with mycobacterial strains differing by hemolytic activity

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