TY - JOUR
T1 - The progression and Early Detection of Subclinical Atherosclerosis (PESA) study: rationale and design
AU - Fernandez-Ortiz, Antonio
AU - Jesus Jimenez-Borreguero, L.
AU - Penalvo, Jose L.
AU - Ordovas, Jose M.
AU - Mocoroa, Agustin
AU - Fernandez-Friera, Leticia
AU - Laclaustra, Martin
AU - Garcia, Laura
AU - Molina, Jesus
AU - Mendiguren, Jose M.
AU - Lopez-Melgar, Beatriz
AU - Martinez de Vega, Vicente
AU - Alonso-Farto, Juan C.
AU - Guallar, Eliseo
AU - Sillesen, Henrik
AU - Rudd, James H. F.
AU - Fayad, Zahi A.
AU - Ibanez, Borja
AU - Sanz, Gines
AU - Fuster, Valentin
N1 - NPP
PY - 2013
Y1 - 2013
N2 - Background: The presence of subclinical atherosclerosis is a likely predictor of cardiovascular events; however, factors associated with the early stages and progression of atherosclerosis are poorly defined.Objective: The PESA study examines the presence of subclinical atherosclerosis by means of noninvasive imaging and prospectively analyzes the determinants associated with its development and progression in a middle-aged population.Methods: The PESA study is an observational, longitudinal and prospective cohort study in a target population of 4000 healthy subjects (40-54 years old, 35% women) based in Madrid (Spain). Recruitment began in June 2010 and will be completed by the end of 2013. Baseline examination consists of (1) assessment for cardiovascular risk factors (including lifestyle and psychosocial factors); (2) screening for subclinical atherosclerosis using 2D/3D ultrasound in carotid, abdominal aorta and iliofemoral arteries, and coronary artery calcium score (CACS) by computed tomography; and (3) blood sampling for determination of traditional risk factors, advanced "omics" and biobanking. In addition, a subgroup of 1300 participants with evidence of atherosclerosis on 2D/3D ultrasound or CACS will undergo a combined F-18-fluorodeoxyglucose-positron emission tomography/magnetic resonance imaging ((18)FDG PET/MRI) study of carotid and iliofemoral arteries. Follow-up at 3 and 6 years will include a repetition of baseline measurements, except for the (18)FDG PET/MRI study, which will be repeated at 6 years.Conclusions: The PESA study is expected to identify new imaging and biological factors associated with the presence and progression of atherosclerosis in asymptomatic people and will help to establish a more personalized management of medical care.
AB - Background: The presence of subclinical atherosclerosis is a likely predictor of cardiovascular events; however, factors associated with the early stages and progression of atherosclerosis are poorly defined.Objective: The PESA study examines the presence of subclinical atherosclerosis by means of noninvasive imaging and prospectively analyzes the determinants associated with its development and progression in a middle-aged population.Methods: The PESA study is an observational, longitudinal and prospective cohort study in a target population of 4000 healthy subjects (40-54 years old, 35% women) based in Madrid (Spain). Recruitment began in June 2010 and will be completed by the end of 2013. Baseline examination consists of (1) assessment for cardiovascular risk factors (including lifestyle and psychosocial factors); (2) screening for subclinical atherosclerosis using 2D/3D ultrasound in carotid, abdominal aorta and iliofemoral arteries, and coronary artery calcium score (CACS) by computed tomography; and (3) blood sampling for determination of traditional risk factors, advanced "omics" and biobanking. In addition, a subgroup of 1300 participants with evidence of atherosclerosis on 2D/3D ultrasound or CACS will undergo a combined F-18-fluorodeoxyglucose-positron emission tomography/magnetic resonance imaging ((18)FDG PET/MRI) study of carotid and iliofemoral arteries. Follow-up at 3 and 6 years will include a repetition of baseline measurements, except for the (18)FDG PET/MRI study, which will be repeated at 6 years.Conclusions: The PESA study is expected to identify new imaging and biological factors associated with the presence and progression of atherosclerosis in asymptomatic people and will help to establish a more personalized management of medical care.
KW - AMERICAN-HEART-ASSOCIATION
KW - ARTERY RISK DEVELOPMENT
KW - CARDIOVASCULAR-DISEASE
KW - VASCULAR-DISEASE
KW - YOUNG-ADULTS
KW - CORONARY
KW - TOMOGRAPHY
KW - UPDATE
KW - CARDIA
U2 - 10.1016/j.ahj.2013.08.024
DO - 10.1016/j.ahj.2013.08.024
M3 - A1: Web of Science-article
SN - 0002-8703
VL - 166
SP - 990
EP - 998
JO - American Heart Journal
JF - American Heart Journal
IS - 6
ER -