The use of Interferon-gamma release assays for tuberculosis screening in international travelers

L Apers, C Yansouni, P Soentjens, M Vekemans, E Bottieau

    Research output: Contribution to journalA2: International peer reviewed article (not A1-type)

    Abstract

    Tuberculosis (TB) infection is relatively frequent among travellers to high incidence-countries, especially in long-term travellers and those involved in health work. It is important to diagnose recent infection, both for the affected individual and to prevent further transmission. Based on published literature, we assess the value of interferon-gamma release assays (IGRAs) as a complement to or replacement of the tuberculin skin test (TST) for the diagnosis of latent TB infection in the setting of a travel clinic. A comparison of available IGRAs with the TST in terms of operating characteristics and practical considerations is presented. We conclude that IGRAs offer some practical advantages that may benefit certain well-defined patient groups of a travel clinic, but that current evidence is incomplete. We identify research questions to better define the role of IGRAs in these populations.
    Original languageEnglish
    JournalCurrent Infectious Disease Reports
    Volume13
    Issue number3
    Pages (from-to)229-235
    Number of pages7
    ISSN1523-3847
    DOIs
    Publication statusPublished - 2011

    Keywords

    • B780-tropical-medicine
    • Bacterial diseases
    • Tuberculosis
    • Mycobacterium tuberculosis
    • Screening
    • Diagnosis
    • Travelers
    • Risk groups
    • Evaluation
    • Interferon-gamma
    • Assays
    • Tuberculin test

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