Therapy of uncomplicated falciparum malaria in Europe: MALTHER; a prospective observational multicentre study

O. Bouchaud; N. Muehlberger; P. Parola; G. Calleri; A. Matteelli; G. Peyerl-Hoffmann; F. Mechai; P. Gautret; J. Clerinx; P.G. Kremsner; T. Jelinek; A. Kaiser; A. Beltrame; M. Schmid; P. Kern; M. Probst; A. Bartoloni; T. Weinke; M.P. Grobusch

doi:10.1186/1475-2875-11-212

Therapy of uncomplicated falciparum malaria in Europe: MALTHER; a prospective observational multicentre study

O. Bouchaud, N. Muehlberger, P. Parola, G. Calleri, A. Matteelli, G. Peyerl-Hoffmann, F. Mechai, P. Gautret, J. Clerinx, P.G. Kremsner, T. Jelinek, A. Kaiser, A. Beltrame, M. Schmid, P. Kern, M. Probst, A. Bartoloni, T. Weinke, M.P. Grobusch

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Abstract

BACKGROUND: Malaria continues to be amongst the most frequent infectious diseases imported to Europe. Whilst European treatment guidelines are based on data from studies carried out in endemic areas, there is a paucity of original prospective treatment data. The objective was to summarize data on treatments to harmonize and optimize treatment for uncomplicated malaria in Europe. METHODS: A prospective observational multicentre study was conducted, assessing tolerance and efficacy of treatment regimens for imported uncomplicated falciparum malaria in adults amongst European centres of tropical and travel medicine. RESULTS: Between December 2003 and 2009, 504 patients were included in 16 centres from five European countries. Eighteen treatment regimens were reported,, the top three being atovaquone-proguanil, mefloquine, and artemether-lumefantrine. Treatments significantly differed with respect to the occurrence of treatment changes (p=0.005) and adverse events (p=0.001), parasite and fever clearance times (p

Original language	English
Journal	Malaria Journal
Volume	11
Issue number	212
Pages (from-to)	1-8
Number of pages	8
ISSN	1475-2875
DOIs	https://doi.org/10.1186/1475-2875-11-212
Publication status	Published - 2012

Keywords

Protozoal diseases
Malaria
Plasmodium falciparum
Vectors
Mosquitoes
Anopheles
Travelers
Treatment
Prospective studies
Assessment
Tolerance
Efficacy
Atovaquone
Proguanil
Mefloquine
Artemether-lumefantrine
Quinine
Treatment regimen
Adverse effects
Clearance
Combination therapy
Europe

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Bouchaud, O., Muehlberger, N., Parola, P., Calleri, G., Matteelli, A., Peyerl-Hoffmann, G., Mechai, F., Gautret, P., Clerinx, J., Kremsner, P. G., Jelinek, T., Kaiser, A., Beltrame, A., Schmid, M., Kern, P., Probst, M., Bartoloni, A., Weinke, T., & Grobusch, M. P. (2012). Therapy of uncomplicated falciparum malaria in Europe: MALTHER; a prospective observational multicentre study. Malaria Journal, 11(212), 1-8. https://doi.org/10.1186/1475-2875-11-212

Bouchaud, O. ; Muehlberger, N. ; Parola, P. ; Calleri, G. ; Matteelli, A. ; Peyerl-Hoffmann, G. ; Mechai, F. ; Gautret, P. ; Clerinx, J. ; Kremsner, P.G. ; Jelinek, T. ; Kaiser, A. ; Beltrame, A. ; Schmid, M. ; Kern, P. ; Probst, M. ; Bartoloni, A. ; Weinke, T. ; Grobusch, M.P. / Therapy of uncomplicated falciparum malaria in Europe: MALTHER; a prospective observational multicentre study. In: Malaria Journal. 2012 ; Vol. 11, No. 212. pp. 1-8.

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title = "Therapy of uncomplicated falciparum malaria in Europe: MALTHER; a prospective observational multicentre study",

abstract = "BACKGROUND: Malaria continues to be amongst the most frequent infectious diseases imported to Europe. Whilst European treatment guidelines are based on data from studies carried out in endemic areas, there is a paucity of original prospective treatment data. The objective was to summarize data on treatments to harmonize and optimize treatment for uncomplicated malaria in Europe. METHODS: A prospective observational multicentre study was conducted, assessing tolerance and efficacy of treatment regimens for imported uncomplicated falciparum malaria in adults amongst European centres of tropical and travel medicine. RESULTS: Between December 2003 and 2009, 504 patients were included in 16 centres from five European countries. Eighteen treatment regimens were reported,, the top three being atovaquone-proguanil, mefloquine, and artemether-lumefantrine. Treatments significantly differed with respect to the occurrence of treatment changes (p=0.005) and adverse events (p=0.001), parasite and fever clearance times (p",

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author = "O. Bouchaud and N. Muehlberger and P. Parola and G. Calleri and A. Matteelli and G. Peyerl-Hoffmann and F. Mechai and P. Gautret and J. Clerinx and P.G. Kremsner and T. Jelinek and A. Kaiser and A. Beltrame and M. Schmid and P. Kern and M. Probst and A. Bartoloni and T. Weinke and M.P. Grobusch",

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Bouchaud, O, Muehlberger, N, Parola, P, Calleri, G, Matteelli, A, Peyerl-Hoffmann, G, Mechai, F, Gautret, P, Clerinx, J, Kremsner, PG, Jelinek, T, Kaiser, A, Beltrame, A, Schmid, M, Kern, P, Probst, M, Bartoloni, A, Weinke, T & Grobusch, MP 2012, 'Therapy of uncomplicated falciparum malaria in Europe: MALTHER; a prospective observational multicentre study', Malaria Journal, vol. 11, no. 212, pp. 1-8. https://doi.org/10.1186/1475-2875-11-212

Therapy of uncomplicated falciparum malaria in Europe: MALTHER; a prospective observational multicentre study. / Bouchaud, O.; Muehlberger, N.; Parola, P.; Calleri, G.; Matteelli, A.; Peyerl-Hoffmann, G.; Mechai, F.; Gautret, P.; Clerinx, J.; Kremsner, P.G.; Jelinek, T.; Kaiser, A.; Beltrame, A.; Schmid, M.; Kern, P.; Probst, M.; Bartoloni, A.; Weinke, T.; Grobusch, M.P.

In: Malaria Journal, Vol. 11, No. 212, 2012, p. 1-8.

Research output: Contribution to journal › A1: Web of Science-article › peer-review

TY - JOUR

T1 - Therapy of uncomplicated falciparum malaria in Europe: MALTHER; a prospective observational multicentre study

AU - Bouchaud, O.

AU - Muehlberger, N.

AU - Parola, P.

AU - Calleri, G.

AU - Matteelli, A.

AU - Peyerl-Hoffmann, G.

AU - Mechai, F.

AU - Gautret, P.

AU - Clerinx, J.

AU - Kremsner, P.G.

AU - Jelinek, T.

AU - Kaiser, A.

AU - Beltrame, A.

AU - Schmid, M.

AU - Kern, P.

AU - Probst, M.

AU - Bartoloni, A.

AU - Weinke, T.

AU - Grobusch, M.P.

N1 - ITG-C9A; DCS; U-TRAVC; JIF; DOI; PDF; E-only; URL; Abstract; DSPACE

PY - 2012

Y1 - 2012

N2 - BACKGROUND: Malaria continues to be amongst the most frequent infectious diseases imported to Europe. Whilst European treatment guidelines are based on data from studies carried out in endemic areas, there is a paucity of original prospective treatment data. The objective was to summarize data on treatments to harmonize and optimize treatment for uncomplicated malaria in Europe. METHODS: A prospective observational multicentre study was conducted, assessing tolerance and efficacy of treatment regimens for imported uncomplicated falciparum malaria in adults amongst European centres of tropical and travel medicine. RESULTS: Between December 2003 and 2009, 504 patients were included in 16 centres from five European countries. Eighteen treatment regimens were reported,, the top three being atovaquone-proguanil, mefloquine, and artemether-lumefantrine. Treatments significantly differed with respect to the occurrence of treatment changes (p=0.005) and adverse events (p=0.001), parasite and fever clearance times (p

AB - BACKGROUND: Malaria continues to be amongst the most frequent infectious diseases imported to Europe. Whilst European treatment guidelines are based on data from studies carried out in endemic areas, there is a paucity of original prospective treatment data. The objective was to summarize data on treatments to harmonize and optimize treatment for uncomplicated malaria in Europe. METHODS: A prospective observational multicentre study was conducted, assessing tolerance and efficacy of treatment regimens for imported uncomplicated falciparum malaria in adults amongst European centres of tropical and travel medicine. RESULTS: Between December 2003 and 2009, 504 patients were included in 16 centres from five European countries. Eighteen treatment regimens were reported,, the top three being atovaquone-proguanil, mefloquine, and artemether-lumefantrine. Treatments significantly differed with respect to the occurrence of treatment changes (p=0.005) and adverse events (p=0.001), parasite and fever clearance times (p

KW - Protozoal diseases

KW - Malaria

KW - Plasmodium falciparum

KW - Vectors

KW - Mosquitoes

KW - Anopheles

KW - Travelers

KW - Treatment

KW - Prospective studies

KW - Assessment

KW - Tolerance

KW - Efficacy

KW - Atovaquone

KW - Proguanil

KW - Mefloquine

KW - Artemether-lumefantrine

KW - Quinine

KW - Treatment regimen

KW - Adverse effects

KW - Clearance

KW - Combination therapy

KW - Europe

U2 - 10.1186/1475-2875-11-212

DO - 10.1186/1475-2875-11-212

M3 - A1: Web of Science-article

C2 - 22720832

VL - 11

SP - 1

EP - 8

JO - Malaria Journal

JF - Malaria Journal

SN - 1475-2875

IS - 212

ER -

Therapy of uncomplicated falciparum malaria in Europe: MALTHER; a prospective observational multicentre study

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Keywords

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