Therapy of uncomplicated falciparum malaria in Europe: MALTHER; a prospective observational multicentre study

O. Bouchaud, N. Muehlberger, P. Parola, G. Calleri, A. Matteelli, G. Peyerl-Hoffmann, F. Mechai, P. Gautret, J. Clerinx, P.G. Kremsner, T. Jelinek, A. Kaiser, A. Beltrame, M. Schmid, P. Kern, M. Probst, A. Bartoloni, T. Weinke, M.P. Grobusch

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BACKGROUND: Malaria continues to be amongst the most frequent infectious diseases imported to Europe. Whilst European treatment guidelines are based on data from studies carried out in endemic areas, there is a paucity of original prospective treatment data. The objective was to summarize data on treatments to harmonize and optimize treatment for uncomplicated malaria in Europe. METHODS: A prospective observational multicentre study was conducted, assessing tolerance and efficacy of treatment regimens for imported uncomplicated falciparum malaria in adults amongst European centres of tropical and travel medicine. RESULTS: Between December 2003 and 2009, 504 patients were included in 16 centres from five European countries. Eighteen treatment regimens were reported,, the top three being atovaquone-proguanil, mefloquine, and artemether-lumefantrine. Treatments significantly differed with respect to the occurrence of treatment changes (p=0.005) and adverse events (p=0.001), parasite and fever clearance times (p
Original languageEnglish
JournalMalaria Journal
Issue number212
Pages (from-to)1-8
Number of pages8
Publication statusPublished - 2012


  • Protozoal diseases
  • Malaria
  • Plasmodium falciparum
  • Vectors
  • Mosquitoes
  • Anopheles
  • Travelers
  • Treatment
  • Prospective studies
  • Assessment
  • Tolerance
  • Efficacy
  • Atovaquone
  • Proguanil
  • Mefloquine
  • Artemether-lumefantrine
  • Quinine
  • Treatment regimen
  • Adverse effects
  • Clearance
  • Combination therapy
  • Europe


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