Therapy of uncomplicated falciparum malaria in Europe: MALTHER; a prospective observational multicentre study

O. Bouchaud, N. Muehlberger, P. Parola, G. Calleri, A. Matteelli, G. Peyerl-Hoffmann, F. Mechai, P. Gautret, J. Clerinx, P.G. Kremsner, T. Jelinek, A. Kaiser, A. Beltrame, M. Schmid, P. Kern, M. Probst, A. Bartoloni, T. Weinke, M.P. Grobusch

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    Abstract

    BACKGROUND: Malaria continues to be amongst the most frequent infectious diseases imported to Europe. Whilst European treatment guidelines are based on data from studies carried out in endemic areas, there is a paucity of original prospective treatment data. The objective was to summarize data on treatments to harmonize and optimize treatment for uncomplicated malaria in Europe. METHODS: A prospective observational multicentre study was conducted, assessing tolerance and efficacy of treatment regimens for imported uncomplicated falciparum malaria in adults amongst European centres of tropical and travel medicine. RESULTS: Between December 2003 and 2009, 504 patients were included in 16 centres from five European countries. Eighteen treatment regimens were reported,, the top three being atovaquone-proguanil, mefloquine, and artemether-lumefantrine. Treatments significantly differed with respect to the occurrence of treatment changes (p=0.005) and adverse events (p=0.001), parasite and fever clearance times (p
    Original languageEnglish
    JournalMalaria Journal
    Volume11
    Issue number212
    Pages (from-to)1-8
    Number of pages8
    ISSN1475-2875
    DOIs
    Publication statusPublished - 2012

    Keywords

    • Protozoal diseases
    • Malaria
    • Plasmodium falciparum
    • Vectors
    • Mosquitoes
    • Anopheles
    • Travelers
    • Treatment
    • Prospective studies
    • Assessment
    • Tolerance
    • Efficacy
    • Atovaquone
    • Proguanil
    • Mefloquine
    • Artemether-lumefantrine
    • Quinine
    • Treatment regimen
    • Adverse effects
    • Clearance
    • Combination therapy
    • Europe

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