Ticks are unlikely to play a role in leprosy transmission in the Comoros (East Africa) as they do not harbour M. leprae DNA

Lena Krausser; Elien Chauvaux; Magalie Van Dyck-Lippens; Amina Yssouf; Younoussa Assoumani; Pablo Tortosa; Bouke Catherine de Jong; Sofie Marijke Braet

doi:10.3389/fmed.2023.1238914

Ticks are unlikely to play a role in leprosy transmission in the Comoros (East Africa) as they do not harbour M. leprae DNA

Lena Krausser, Elien Chauvaux, Magalie Van Dyck-Lippens, Amina Yssouf, Younoussa Assoumani, Pablo Tortosa, Bouke Catherine de Jong, Sofie Marijke Braet

Mycobacteriology

Research output: Contribution to journal › A1: Web of Science-article › peer-review

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Abstract

INTRODUCTION: Leprosy, one of the oldest known human diseases, continues to pose a global challenge for disease control due to an incomplete understanding of its transmission pathways. Ticks have been proposed as a potential contributor in leprosy transmission due to their importance as vectors for other infectious diseases.

METHODS: In 2010, a sampling of ticks residing on cattle was conducted on the islands Grande Comore, Anjouan, and Mohéli which constitute the Union of the Comoros where leprosy remains endemic. To investigate the potential role of ticks as a vector in transmission of leprosy disease, molecular analyses were conducted.

RESULTS: Out of the 526 ticks analysed, none were found to harbour Mycobacterium leprae DNA, as determined by a quantitative polymerase chain reaction (qPCR) assay targeting a family of dispersed repeats (RLEP) specific to M. leprae.

DISCUSSION: Therefore, our results suggest that in the Union of the Comoros, ticks are an unlikely vector for M. leprae.

Original language	English
Article number	1238914
Journal	Frontiers in Medicine
Volume	10
Number of pages	5
ISSN	2296-858X
DOIs	https://doi.org/10.3389/fmed.2023.1238914
Publication status	Published - 2023

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10.3389/fmed.2023.1238914

2023fmed1238914Final published version, 317 KBLicence: CC BY

Using novel molecular approaches to understand the transmission dynamics of Mycobacterium leprae in the Comoros
Braet, S., de Jong, B. & Rigouts, L.
11/04/19 → 7/12/23
Project: PhD-project

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@article{01c0b6c305d640eeab65b95c3a381446,

title = "Ticks are unlikely to play a role in leprosy transmission in the Comoros (East Africa) as they do not harbour M. leprae DNA",

abstract = "INTRODUCTION: Leprosy, one of the oldest known human diseases, continues to pose a global challenge for disease control due to an incomplete understanding of its transmission pathways. Ticks have been proposed as a potential contributor in leprosy transmission due to their importance as vectors for other infectious diseases.METHODS: In 2010, a sampling of ticks residing on cattle was conducted on the islands Grande Comore, Anjouan, and Moh{\'e}li which constitute the Union of the Comoros where leprosy remains endemic. To investigate the potential role of ticks as a vector in transmission of leprosy disease, molecular analyses were conducted.RESULTS: Out of the 526 ticks analysed, none were found to harbour Mycobacterium leprae DNA, as determined by a quantitative polymerase chain reaction (qPCR) assay targeting a family of dispersed repeats (RLEP) specific to M. leprae.DISCUSSION: Therefore, our results suggest that in the Union of the Comoros, ticks are an unlikely vector for M. leprae.",

author = "Lena Krausser and Elien Chauvaux and {Van Dyck-Lippens}, Magalie and Amina Yssouf and Younoussa Assoumani and Pablo Tortosa and {de Jong}, {Bouke Catherine} and Braet, {Sofie Marijke}",

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year = "2023",

doi = "10.3389/fmed.2023.1238914",

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journal = "Frontiers in Medicine",

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TY - JOUR

T1 - Ticks are unlikely to play a role in leprosy transmission in the Comoros (East Africa) as they do not harbour M. leprae DNA

AU - Krausser, Lena

AU - Chauvaux, Elien

AU - Van Dyck-Lippens, Magalie

AU - Yssouf, Amina

AU - Assoumani, Younoussa

AU - Tortosa, Pablo

AU - de Jong, Bouke Catherine

AU - Braet, Sofie Marijke

N1 - FTX; DOAJ; (CC BY)

PY - 2023

Y1 - 2023

N2 - INTRODUCTION: Leprosy, one of the oldest known human diseases, continues to pose a global challenge for disease control due to an incomplete understanding of its transmission pathways. Ticks have been proposed as a potential contributor in leprosy transmission due to their importance as vectors for other infectious diseases.METHODS: In 2010, a sampling of ticks residing on cattle was conducted on the islands Grande Comore, Anjouan, and Mohéli which constitute the Union of the Comoros where leprosy remains endemic. To investigate the potential role of ticks as a vector in transmission of leprosy disease, molecular analyses were conducted.RESULTS: Out of the 526 ticks analysed, none were found to harbour Mycobacterium leprae DNA, as determined by a quantitative polymerase chain reaction (qPCR) assay targeting a family of dispersed repeats (RLEP) specific to M. leprae.DISCUSSION: Therefore, our results suggest that in the Union of the Comoros, ticks are an unlikely vector for M. leprae.

AB - INTRODUCTION: Leprosy, one of the oldest known human diseases, continues to pose a global challenge for disease control due to an incomplete understanding of its transmission pathways. Ticks have been proposed as a potential contributor in leprosy transmission due to their importance as vectors for other infectious diseases.METHODS: In 2010, a sampling of ticks residing on cattle was conducted on the islands Grande Comore, Anjouan, and Mohéli which constitute the Union of the Comoros where leprosy remains endemic. To investigate the potential role of ticks as a vector in transmission of leprosy disease, molecular analyses were conducted.RESULTS: Out of the 526 ticks analysed, none were found to harbour Mycobacterium leprae DNA, as determined by a quantitative polymerase chain reaction (qPCR) assay targeting a family of dispersed repeats (RLEP) specific to M. leprae.DISCUSSION: Therefore, our results suggest that in the Union of the Comoros, ticks are an unlikely vector for M. leprae.

U2 - 10.3389/fmed.2023.1238914

DO - 10.3389/fmed.2023.1238914

M3 - A1: Web of Science-article

C2 - 37859857

SN - 2296-858X

VL - 10

JO - Frontiers in Medicine

JF - Frontiers in Medicine

M1 - 1238914

ER -

Ticks are unlikely to play a role in leprosy transmission in the Comoros (East Africa) as they do not harbour M. leprae DNA

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Using novel molecular approaches to understand the transmission dynamics of Mycobacterium leprae in the Comoros

Cite this