Time to initiation of multidrug-resistant tuberculosis treatment and its relation with outcome in a high incidence district in Lima, Peru

L Otero; A De Orbegoso; A F Navarro; J Ríos; T Párraga; E Gotuzzo; C Seas; P Van der Stuyft

doi:10.1111/tmi.12430

Time to initiation of multidrug-resistant tuberculosis treatment and its relation with outcome in a high incidence district in Lima, Peru

L Otero, A De Orbegoso, A F Navarro, J Ríos, T Párraga, E Gotuzzo, C Seas, P Van der Stuyft

Research output: Contribution to journal › A1: Web of Science-article › peer-review

Abstract

OBJECTIVE: To determine the time from diagnosis to start of multidrug resistant tuberculosis (MDR TB) treatment in Lima, Peru.

METHODS: We studied new smear-positive TB adults that were started on MDR TB treatment or that were switched to it between June 2008 and December 2011.

RESULTS: Time from the first positive smear to MDR-TB treatment was >30 days in 35% (13/37) of patients. Among the 27% (24/88) of patients that switched to MDR-TB treatment, time from the last dose of a drug-susceptible regimen was >30 days.

CONCLUSION: Start of and switching to MDR TB treatment is still delayed.

Original language	English
Journal	Tropical Medicine and International Health
Volume	20
Issue number	3
Pages (from-to)	322-325
Number of pages	4
ISSN	1360-2276
DOIs	https://doi.org/10.1111/tmi.12430
Publication status	Published - 2015

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title = "Time to initiation of multidrug-resistant tuberculosis treatment and its relation with outcome in a high incidence district in Lima, Peru",

abstract = "OBJECTIVE: To determine the time from diagnosis to start of multidrug resistant tuberculosis (MDR TB) treatment in Lima, Peru.METHODS: We studied new smear-positive TB adults that were started on MDR TB treatment or that were switched to it between June 2008 and December 2011.RESULTS: Time from the first positive smear to MDR-TB treatment was >30 days in 35% (13/37) of patients. Among the 27% (24/88) of patients that switched to MDR-TB treatment, time from the last dose of a drug-susceptible regimen was >30 days.CONCLUSION: Start of and switching to MDR TB treatment is still delayed.",

keywords = "Adult, Antitubercular Agents, Drug Substitution, Female, Humans, Incidence, Male, Outcome Assessment (Health Care), Peru, Retrospective Studies, Time Factors, Tuberculosis, Multidrug-Resistant, Tuberculosis, Pulmonary",

author = "L Otero and {De Orbegoso}, A and Navarro, {A F} and J R{\'i}os and T P{\'a}rraga and E Gotuzzo and C Seas and {Van der Stuyft}, P",

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year = "2015",

doi = "10.1111/tmi.12430",

language = "English",

volume = "20",

pages = "322--325",

journal = "Tropical Medicine and International Health",

issn = "1360-2276",

publisher = "John Wiley & Sons",

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TY - JOUR

T1 - Time to initiation of multidrug-resistant tuberculosis treatment and its relation with outcome in a high incidence district in Lima, Peru

AU - Otero, L

AU - De Orbegoso, A

AU - Navarro, A F

AU - Ríos, J

AU - Párraga, T

AU - Gotuzzo, E

AU - Seas, C

AU - Van der Stuyft, P

PY - 2015

Y1 - 2015

N2 - OBJECTIVE: To determine the time from diagnosis to start of multidrug resistant tuberculosis (MDR TB) treatment in Lima, Peru.METHODS: We studied new smear-positive TB adults that were started on MDR TB treatment or that were switched to it between June 2008 and December 2011.RESULTS: Time from the first positive smear to MDR-TB treatment was >30 days in 35% (13/37) of patients. Among the 27% (24/88) of patients that switched to MDR-TB treatment, time from the last dose of a drug-susceptible regimen was >30 days.CONCLUSION: Start of and switching to MDR TB treatment is still delayed.

AB - OBJECTIVE: To determine the time from diagnosis to start of multidrug resistant tuberculosis (MDR TB) treatment in Lima, Peru.METHODS: We studied new smear-positive TB adults that were started on MDR TB treatment or that were switched to it between June 2008 and December 2011.RESULTS: Time from the first positive smear to MDR-TB treatment was >30 days in 35% (13/37) of patients. Among the 27% (24/88) of patients that switched to MDR-TB treatment, time from the last dose of a drug-susceptible regimen was >30 days.CONCLUSION: Start of and switching to MDR TB treatment is still delayed.

KW - Adult

KW - Antitubercular Agents

KW - Drug Substitution

KW - Female

KW - Humans

KW - Incidence

KW - Male

KW - Outcome Assessment (Health Care)

KW - Peru

KW - Retrospective Studies

KW - Time Factors

KW - Tuberculosis, Multidrug-Resistant

KW - Tuberculosis, Pulmonary

U2 - 10.1111/tmi.12430

DO - 10.1111/tmi.12430

M3 - A1: Web of Science-article

C2 - 25429916

SN - 1360-2276

VL - 20

SP - 322

EP - 325

JO - Tropical Medicine and International Health

JF - Tropical Medicine and International Health

IS - 3

ER -

Time to initiation of multidrug-resistant tuberculosis treatment and its relation with outcome in a high incidence district in Lima, Peru

Abstract

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