Transmission of NS5A-inhibitor resistance-associated substitutions among men who have sex with men recently infected with hepatitis C virus genotype 1a

Stephanie Popping, Rosanne Verwijs, Lize Cuypers, Mark Claassen, Guido van den Berk, Anja De Weggheleire, Joop Arends, Anne Boerekamps, Richard Molenkamp, Marion Koopmans, Annelies Verbon, Charles Boucher, Bart Rijnders, David van de Vijver

Research output: Contribution to journalA1: Web of Science-article

Abstract

The transmission of direct-acting antiviral resistance-associated substitutions (RAS) could hamper hepatitis C virus (HCV) cure rates and elimination efforts. A phylogenetic analysis of 87 men who have sex with men recently infected with HCV genotype 1a placed one-third (28/87) in a large cluster, in which 96% harbored NS5A M28V RAS.

Original languageEnglish
JournalClinical Infectious Diseases
Volume71
Issue number8
Pages (from-to)e215-e217
Number of pages3
ISSN1058-4838
DOIs
Publication statusPublished - 2020

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