Transmission of NS5A-inhibitor resistance-associated substitutions among men who have sex with men recently infected with hepatitis C virus genotype 1a

Stephanie Popping; Rosanne Verwijs; Lize Cuypers; Mark Claassen; Guido van den Berk; Anja De Weggheleire; Joop Arends; Anne Boerekamps; Richard Molenkamp; Marion Koopmans; Annelies Verbon; Charles Boucher; Bart Rijnders; David van de Vijver

doi:10.1093/cid/ciaa145

Transmission of NS5A-inhibitor resistance-associated substitutions among men who have sex with men recently infected with hepatitis C virus genotype 1a

Stephanie Popping
, Rosanne Verwijs
, Lize Cuypers
, Mark Claassen
, Guido van den Berk
, Anja De Weggheleire
, Joop Arends
, Anne Boerekamps
, Richard Molenkamp
, Marion Koopmans
, Annelies Verbon
, Charles Boucher
, Bart Rijnders
, David van de Vijver

Neglected Tropical Diseases

Research output: Contribution to journal › A1: Peer-reviewed journal articles › peer-review

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Abstract

The transmission of direct-acting antiviral resistance-associated substitutions (RAS) could hamper hepatitis C virus (HCV) cure rates and elimination efforts. A phylogenetic analysis of 87 men who have sex with men recently infected with HCV genotype 1a placed one-third (28/87) in a large cluster, in which 96% harbored NS5A M28V RAS.

Original language	English
Journal	Clinical Infectious Diseases
Volume	71
Issue number	8
Pages (from-to)	e215-e217
Number of pages	3
ISSN	1058-4838
DOIs	https://doi.org/10.1093/cid/ciaa145
Publication status	Published - 2020

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10.1093/cid/ciaa145Licence: CC BY-NC-ND

2020cidie215Final published version, 531 KBLicence: CC BY-NC-ND

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Popping, S., Verwijs, R., Cuypers, L., Claassen, M., van den Berk, G., De Weggheleire, A., Arends, J., Boerekamps, A., Molenkamp, R., Koopmans, M., Verbon, A., Boucher, C., Rijnders, B., & van de Vijver, D. (2020). Transmission of NS5A-inhibitor resistance-associated substitutions among men who have sex with men recently infected with hepatitis C virus genotype 1a. Clinical Infectious Diseases, 71(8), e215-e217. https://doi.org/10.1093/cid/ciaa145

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title = "Transmission of NS5A-inhibitor resistance-associated substitutions among men who have sex with men recently infected with hepatitis C virus genotype 1a",

abstract = "The transmission of direct-acting antiviral resistance-associated substitutions (RAS) could hamper hepatitis C virus (HCV) cure rates and elimination efforts. A phylogenetic analysis of 87 men who have sex with men recently infected with HCV genotype 1a placed one-third (28/87) in a large cluster, in which 96\% harbored NS5A M28V RAS.",

author = "Stephanie Popping and Rosanne Verwijs and Lize Cuypers and Mark Claassen and \{van den Berk\}, Guido and \{De Weggheleire\}, Anja and Joop Arends and Anne Boerekamps and Richard Molenkamp and Marion Koopmans and Annelies Verbon and Charles Boucher and Bart Rijnders and \{van de Vijver\}, David",

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year = "2020",

doi = "10.1093/cid/ciaa145",

language = "English",

volume = "71",

pages = "e215--e217",

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Popping, S, Verwijs, R, Cuypers, L, Claassen, M, van den Berk, G, De Weggheleire, A, Arends, J, Boerekamps, A, Molenkamp, R, Koopmans, M, Verbon, A, Boucher, C, Rijnders, B & van de Vijver, D 2020, 'Transmission of NS5A-inhibitor resistance-associated substitutions among men who have sex with men recently infected with hepatitis C virus genotype 1a', Clinical Infectious Diseases, vol. 71, no. 8, pp. e215-e217. https://doi.org/10.1093/cid/ciaa145

Transmission of NS5A-inhibitor resistance-associated substitutions among men who have sex with men recently infected with hepatitis C virus genotype 1a. / Popping, Stephanie; Verwijs, Rosanne; Cuypers, Lize et al.
In: Clinical Infectious Diseases, Vol. 71, No. 8, 2020, p. e215-e217.

Research output: Contribution to journal › A1: Peer-reviewed journal articles › peer-review

TY - JOUR

T1 - Transmission of NS5A-inhibitor resistance-associated substitutions among men who have sex with men recently infected with hepatitis C virus genotype 1a

AU - Popping, Stephanie

AU - Verwijs, Rosanne

AU - Cuypers, Lize

AU - Claassen, Mark

AU - van den Berk, Guido

AU - De Weggheleire, Anja

AU - Arends, Joop

AU - Boerekamps, Anne

AU - Molenkamp, Richard

AU - Koopmans, Marion

AU - Verbon, Annelies

AU - Boucher, Charles

AU - Rijnders, Bart

AU - van de Vijver, David

N1 - OGOA; FTX; (CC BY-NC-ND 4.0)

PY - 2020

Y1 - 2020

N2 - The transmission of direct-acting antiviral resistance-associated substitutions (RAS) could hamper hepatitis C virus (HCV) cure rates and elimination efforts. A phylogenetic analysis of 87 men who have sex with men recently infected with HCV genotype 1a placed one-third (28/87) in a large cluster, in which 96% harbored NS5A M28V RAS.

AB - The transmission of direct-acting antiviral resistance-associated substitutions (RAS) could hamper hepatitis C virus (HCV) cure rates and elimination efforts. A phylogenetic analysis of 87 men who have sex with men recently infected with HCV genotype 1a placed one-third (28/87) in a large cluster, in which 96% harbored NS5A M28V RAS.

U2 - 10.1093/cid/ciaa145

DO - 10.1093/cid/ciaa145

M3 - A1: Peer-reviewed journal articles

C2 - 32055843

SN - 1058-4838

VL - 71

SP - e215-e217

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

IS - 8

ER -

Transmission of NS5A-inhibitor resistance-associated substitutions among men who have sex with men recently infected with hepatitis C virus genotype 1a

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