Treatment outcome of imported cutaneous leishmaniasis among travelers and migrants infected with Leishmania major and Leishmania tropica: a retrospective study in European centers 2013 to 2019

Hedvig Glans, Leif Dotevall, Gert Van der Auwera, Aldert Bart, Johannes Blum, Pierre Buffet, Romain Guery, Jean-Pierre Gangneux, Saskia van Henten, Gundel Harms, Stefania Varani, Florence Robert-Gangneux, Robert Rongisch, Bjorn Andersson, Maria Bradley

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Abstract

Objectives: Cutaneous leishmaniasis (CL) in Asia, Northern, and Sub-Saharan Africa is mainly caused by Leishmania major and Leishmania tropica. We describe and evaluate the treatment outcome of CL among travelers and migrants in Europe.Methods: We conducted a retrospective study of parasitological confirmed CL cases caused by L. major and L. tropica during 2013-2019 in Europe. Data were collected from medical records and databases within the LeishMan network.Results: Of 206 included cases of CL, 75 were identified as L. major and 131 as L. tropica. Of patients with L. tropica infection, 80% were migrants, whereas 53% of patients with L. major infection had been visiting friends and relatives. Among patients with L. tropica, 48% were younger than 15 years. Pentavalent antimony cured 73% ( L. major ) and 78% ( L. tropica) of patients. The cure rate for intralesional administration was 86% and 67% for systemic, on L. tropica. Liposomal amphotericin B had a cure rate of 44-63%. Conclusion: L. major infections were mostly found in individuals visiting friends and relatives, whereas L. tropica were mainly identified in migrants. No patients with L. major relapsed. Pentavalent antimony, liposomal amphotericin B, and cryotherapy had cure rates in accordance with previous studies.(c) 2022 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.This is an open access article under the CC BY license ( http://creativecommons.org/licenses/by/4.0/ )

Original languageEnglish
JournalInternational Journal of Infectious Diseases
Volume122
Pages (from-to)375-381
Number of pages7
ISSN1201-9712
DOIs
Publication statusPublished - 2022

Keywords

  • Cutaneous leishmaniasis
  • Leishmania major
  • Leishmania tropica
  • Treatment
  • Outcome
  • LIPOSOMAL AMPHOTERICIN-B
  • MEGLUMINE ANTIMONIATE
  • MUCOSAL LEISHMANIASIS
  • CLINICAL-TRIAL
  • EFFICACY
  • CRYOTHERAPY
  • FLUCONAZOLE
  • PAROMOMYCIN
  • FORMULATION

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