Tuberculosis drug resistance testing by molecular methods: opportunities and challenges in resource limited settings

G Abebe, F Paasch, L Apers, L Rigouts, R Colebunders

    Research output: Contribution to journalA1: Web of Science-article

    Abstract

    One of the greatest threats to global tuberculosis (TB) control is the growing prevalence of drug-resistant bacilli. Correctly diagnosing drug-resistant TB patients is more problematic in resource-limited settings as there is no or limited infrastructure for drug susceptibility testing (DST) of TB bacilli. The conventional phenotypic DST method for TB takes weeks before declaring the results and initiating proper anti-TB treatment. Molecular DST offers advantages over the phenotypic methods mainly because of the short turn around time. This review summarizes the different molecular DST methods for TB and discusses challenges and opportunities in implementing them in resource-limited settings.
    Original languageEnglish
    JournalJournal of Microbiological Methods
    Volume84
    Issue number2
    Pages (from-to)155-160
    Number of pages6
    ISSN0167-7012
    DOIs
    Publication statusPublished - 2011

    Keywords

    • B780-tropical-medicine
    • Bacterial diseases
    • Tuberculosis
    • Mycobacterium tuberculosis
    • Diagnosis
    • Drug resistance
    • Drug susceptibility
    • Testing
    • Molecular
    • Real-time
    • Polymerase chain reaction
    • PCR
    • Solid phase cytometry
    • Hybridization assay
    • Sequencing
    • Barriers
    • Efficiency
    • Laboratory techniques and procedures
    • Review of the literature

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