Two distinct lineages of chikungunya virus cocirculated in Aruba during the 2014-2015 epidemic

Juthamas Phadungsombat; Aekkachai Tuekprakhon; Lieselotte Cnops; Johan Michiels; Riemsdijk van den Berg; Emi E Nakayama; Tatsuo Shioda; Kevin K Ariën; Ralph Huits

doi:10.1016/j.meegid.2019.104129

Two distinct lineages of chikungunya virus cocirculated in Aruba during the 2014-2015 epidemic

Juthamas Phadungsombat, Aekkachai Tuekprakhon, Lieselotte Cnops, Johan Michiels, Riemsdijk van den Berg, Emi E Nakayama, Tatsuo Shioda, Kevin K Ariën, Ralph Huits

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Abstract

Chikungunya virus (CHIKV), a positive-sense, single-stranded RNA virus in the family Togaviridae, is transmitted by Aedes mosquitoes. Of three known CHIKV genotypes, the Asian genotype was introduced into the Caribbean islands and rapidly spread throughout Central and South Americas. We previously found patients with symptoms compatible with chikungunya fever in 2014-2015 in Aruba, a Caribbean island of 180 km2. We here describe the full genome sequences of eight CHIKV strains isolated from patient sera of the Aruban outbreak. Phylogenetic analysis revealed that two closely related but distinct lineages of Asian-genotype CHIKV circulated simultaneously during the epidemic in 2014-2015. These results suggested that CHIKV was introduced into Aruba more than once in a short period, reflecting the importance of Aruba as a travel hub within the region.

Original language	English
Article number	104129
Journal	Infection, Genetics and Evolution
Volume	78
Number of pages	7
ISSN	1567-1348
DOIs	https://doi.org/10.1016/j.meegid.2019.104129
Publication status	Published - 2020

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@article{e1507ea3f1474ac8a90965e86c77677d,

title = "Two distinct lineages of chikungunya virus cocirculated in Aruba during the 2014-2015 epidemic",

abstract = "Chikungunya virus (CHIKV), a positive-sense, single-stranded RNA virus in the family Togaviridae, is transmitted by Aedes mosquitoes. Of three known CHIKV genotypes, the Asian genotype was introduced into the Caribbean islands and rapidly spread throughout Central and South Americas. We previously found patients with symptoms compatible with chikungunya fever in 2014-2015 in Aruba, a Caribbean island of 180 km2. We here describe the full genome sequences of eight CHIKV strains isolated from patient sera of the Aruban outbreak. Phylogenetic analysis revealed that two closely related but distinct lineages of Asian-genotype CHIKV circulated simultaneously during the epidemic in 2014-2015. These results suggested that CHIKV was introduced into Aruba more than once in a short period, reflecting the importance of Aruba as a travel hub within the region.",

author = "Juthamas Phadungsombat and Aekkachai Tuekprakhon and Lieselotte Cnops and Johan Michiels and {van den Berg}, Riemsdijk and Nakayama, {Emi E} and Tatsuo Shioda and Ari{\"e}n, {Kevin K} and Ralph Huits",

year = "2020",

doi = "10.1016/j.meegid.2019.104129",

language = "English",

volume = "78",

journal = "Infection, Genetics and Evolution",

issn = "1567-1348",

publisher = "Elsevier",

}

TY - JOUR

T1 - Two distinct lineages of chikungunya virus cocirculated in Aruba during the 2014-2015 epidemic

AU - Phadungsombat, Juthamas

AU - Tuekprakhon, Aekkachai

AU - Cnops, Lieselotte

AU - Michiels, Johan

AU - van den Berg, Riemsdijk

AU - Nakayama, Emi E

AU - Shioda, Tatsuo

AU - Ariën, Kevin K

AU - Huits, Ralph

PY - 2020

Y1 - 2020

N2 - Chikungunya virus (CHIKV), a positive-sense, single-stranded RNA virus in the family Togaviridae, is transmitted by Aedes mosquitoes. Of three known CHIKV genotypes, the Asian genotype was introduced into the Caribbean islands and rapidly spread throughout Central and South Americas. We previously found patients with symptoms compatible with chikungunya fever in 2014-2015 in Aruba, a Caribbean island of 180 km2. We here describe the full genome sequences of eight CHIKV strains isolated from patient sera of the Aruban outbreak. Phylogenetic analysis revealed that two closely related but distinct lineages of Asian-genotype CHIKV circulated simultaneously during the epidemic in 2014-2015. These results suggested that CHIKV was introduced into Aruba more than once in a short period, reflecting the importance of Aruba as a travel hub within the region.

AB - Chikungunya virus (CHIKV), a positive-sense, single-stranded RNA virus in the family Togaviridae, is transmitted by Aedes mosquitoes. Of three known CHIKV genotypes, the Asian genotype was introduced into the Caribbean islands and rapidly spread throughout Central and South Americas. We previously found patients with symptoms compatible with chikungunya fever in 2014-2015 in Aruba, a Caribbean island of 180 km2. We here describe the full genome sequences of eight CHIKV strains isolated from patient sera of the Aruban outbreak. Phylogenetic analysis revealed that two closely related but distinct lineages of Asian-genotype CHIKV circulated simultaneously during the epidemic in 2014-2015. These results suggested that CHIKV was introduced into Aruba more than once in a short period, reflecting the importance of Aruba as a travel hub within the region.

U2 - 10.1016/j.meegid.2019.104129

DO - 10.1016/j.meegid.2019.104129

M3 - A1: Web of Science-article

C2 - 31786339

SN - 1567-1348

VL - 78

JO - Infection, Genetics and Evolution

JF - Infection, Genetics and Evolution

M1 - 104129

ER -

Two distinct lineages of chikungunya virus cocirculated in Aruba during the 2014-2015 epidemic

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