Two mutations in dihydrofolate reductase combined with one in the dihydropteroate synthase gene predict sulphadoxine-pyrimethamine parasitological failure in Ugandan children with uncomplicated falciparum malaria

AO Talisuna; A Nalunkuma-Kazibwe; P Langi; TK Mutabingwa; WW Watkins; E Van Marck; TG Egwang; U D'Alessandro

doi:10.1016/j.meegid.2004.04.002

Two mutations in dihydrofolate reductase combined with one in the dihydropteroate synthase gene predict sulphadoxine-pyrimethamine parasitological failure in Ugandan children with uncomplicated falciparum malaria

AO Talisuna, A Nalunkuma-Kazibwe, P Langi, TK Mutabingwa, WW Watkins, E Van Marck, TG Egwang, U D'Alessandro

Research output: Contribution to journal › A1: Web of Science-article › peer-review

Original language	English
Journal	Infection, Genetics and Evolution
Volume	4
Issue number	2
Pages (from-to)	321-327
ISSN	1567-1348
DOIs	https://doi.org/10.1016/j.meegid.2004.04.002
Publication status	Published - 2004

Keywords

B780-tropical-medicine
Protozoal diseases
Malaria
Plasmodium falciparum
Antimalarials
Sulfadoxine-pyrimethamine
Drug resistance
Prediction
Risk populations
Screening
In vivo
Molecular markers
Point mutations
Dihydrofolate reductase
Dihydropteroate synthase
Uganda
Africa-East

Access to Document

10.1016/j.meegid.2004.04.002

http://lib.itg.be/pdf/itg/2004/2004igev0321.pdf

Cite this

Talisuna, AO., Nalunkuma-Kazibwe, A., Langi, P., Mutabingwa, TK., Watkins, WW., Van Marck, E., Egwang, TG., & D'Alessandro, U. (2004). Two mutations in dihydrofolate reductase combined with one in the dihydropteroate synthase gene predict sulphadoxine-pyrimethamine parasitological failure in Ugandan children with uncomplicated falciparum malaria. Infection, Genetics and Evolution, 4(2), 321-327. https://doi.org/10.1016/j.meegid.2004.04.002

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title = "Two mutations in dihydrofolate reductase combined with one in the dihydropteroate synthase gene predict sulphadoxine-pyrimethamine parasitological failure in Ugandan children with uncomplicated falciparum malaria",

keywords = "B780-tropical-medicine, Protozoal diseases, Malaria, Plasmodium falciparum, Antimalarials, Sulfadoxine-pyrimethamine, Drug resistance, Prediction, Risk populations, Screening, In vivo, Molecular markers, Point mutations, Dihydrofolate reductase, Dihydropteroate synthase, Uganda, Africa-East",

author = "AO Talisuna and A Nalunkuma-Kazibwe and P Langi and TK Mutabingwa and WW Watkins and {Van Marck}, E and TG Egwang and U D'Alessandro",

note = "ITG-P1B; ITG-PLA; PARAS; U-MALAR; JIF; DOI; PDF",

year = "2004",

doi = "10.1016/j.meegid.2004.04.002",

language = "English",

volume = "4",

pages = "321--327",

journal = "Infection, Genetics and Evolution",

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Talisuna, AO, Nalunkuma-Kazibwe, A, Langi, P, Mutabingwa, TK, Watkins, WW, Van Marck, E, Egwang, TG & D'Alessandro, U 2004, 'Two mutations in dihydrofolate reductase combined with one in the dihydropteroate synthase gene predict sulphadoxine-pyrimethamine parasitological failure in Ugandan children with uncomplicated falciparum malaria', Infection, Genetics and Evolution, vol. 4, no. 2, pp. 321-327. https://doi.org/10.1016/j.meegid.2004.04.002

Two mutations in dihydrofolate reductase combined with one in the dihydropteroate synthase gene predict sulphadoxine-pyrimethamine parasitological failure in Ugandan children with uncomplicated falciparum malaria. / Talisuna, AO; Nalunkuma-Kazibwe, A; Langi, P et al.
In: Infection, Genetics and Evolution, Vol. 4, No. 2, 2004, p. 321-327.

Research output: Contribution to journal › A1: Web of Science-article › peer-review

TY - JOUR

T1 - Two mutations in dihydrofolate reductase combined with one in the dihydropteroate synthase gene predict sulphadoxine-pyrimethamine parasitological failure in Ugandan children with uncomplicated falciparum malaria

AU - Talisuna, AO

AU - Nalunkuma-Kazibwe, A

AU - Langi, P

AU - Mutabingwa, TK

AU - Watkins, WW

AU - Van Marck, E

AU - Egwang, TG

AU - D'Alessandro, U

N1 - ITG-P1B; ITG-PLA; PARAS; U-MALAR; JIF; DOI; PDF

PY - 2004

Y1 - 2004

KW - B780-tropical-medicine

KW - Protozoal diseases

KW - Malaria

KW - Plasmodium falciparum

KW - Antimalarials

KW - Sulfadoxine-pyrimethamine

KW - Drug resistance

KW - Prediction

KW - Risk populations

KW - Screening

KW - In vivo

KW - Molecular markers

KW - Point mutations

KW - Dihydrofolate reductase

KW - Dihydropteroate synthase

KW - Uganda

KW - Africa-East

U2 - 10.1016/j.meegid.2004.04.002

DO - 10.1016/j.meegid.2004.04.002

M3 - A1: Web of Science-article

SN - 1567-1348

VL - 4

SP - 321

EP - 327

JO - Infection, Genetics and Evolution

JF - Infection, Genetics and Evolution

IS - 2

ER -

Talisuna AO, Nalunkuma-Kazibwe A, Langi P, Mutabingwa TK, Watkins WW, Van Marck E et al. Two mutations in dihydrofolate reductase combined with one in the dihydropteroate synthase gene predict sulphadoxine-pyrimethamine parasitological failure in Ugandan children with uncomplicated falciparum malaria. Infection, Genetics and Evolution. 2004;4(2):321-327. doi: 10.1016/j.meegid.2004.04.002