Updating the approaches to define susceptibility and resistance to anti-tuberculosis agents: implications for diagnosis and treatment

Antimycobacterial Susceptibility T

doi:10.1183/13993003.00166-2022

Updating the approaches to define susceptibility and resistance to anti-tuberculosis agents: implications for diagnosis and treatment

Antimycobacterial Susceptibility T

Mycobacteriology

Research output: Contribution to journal › A1: Web of Science-article › peer-review

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Abstract

Inappropriately high breakpoints have resulted in systematic false-susceptible AST results to anti-TB drugs. MIC, PK/PD and clinical outcome data should be combined when setting breakpoints to minimise the emergence and spread of antimicrobial resistance. https://bit.ly/3i43wb6

Original language	English
Article number	2200166
Journal	European Respiratory Journal
Volume	59
Issue number	4
Number of pages	11
ISSN	0903-1936
DOIs	https://doi.org/10.1183/13993003.00166-2022
Publication status	Published - 2022

Keywords

Antitubercular Agents/pharmacology
Drug Resistance, Bacterial
Drug Resistance, Multiple, Bacterial
Humans
Microbial Sensitivity Tests
Mycobacterium tuberculosis
Tuberculosis, Multidrug-Resistant/diagnosis

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10.1183/13993003.00166-2022Licence: CC BY

2022erjo2200166Final published version, 406 KBLicence: CC BY

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title = "Updating the approaches to define susceptibility and resistance to anti-tuberculosis agents: implications for diagnosis and treatment",

abstract = " Inappropriately high breakpoints have resulted in systematic false-susceptible AST results to anti-TB drugs. MIC, PK/PD and clinical outcome data should be combined when setting breakpoints to minimise the emergence and spread of antimicrobial resistance. https://bit.ly/3i43wb6 ",

keywords = "Antitubercular Agents/pharmacology, Drug Resistance, Bacterial, Drug Resistance, Multiple, Bacterial, Humans, Microbial Sensitivity Tests, Mycobacterium tuberculosis, Tuberculosis, Multidrug-Resistant/diagnosis",

author = "{Antimycobacterial Susceptibility T} and Georghiou, {Sophia B.} and Rodwell, {Timothy C.} and Alexei Korobitsyn and Abbadi, {Said H.} and Kanchan Ajbani and Jan-Willem Alffenaar and David Alland and Nataly Alvarez and Sonke Andres and Elisa Ardizzoni and Alexandra Aubry and Rossella Baldan and Marie Ballif and Ivan Barilar and Bottger, {Erik C.} and Soumitesh Chakravorty and Claxton, {Pauline M.} and Cirillo, {Daniela M.} and Inaki Comas and Chris Coulter and Denkinger, {Claudia M.} and Brigitta Derendinger and Desmond, {Edward P.} and {de Steenwinkel}, {Jurriaan E. M.} and Keertan Dheda and Diacon, {Andreas H.} and Dolinger, {David L.} and Dooley, {Kelly E.} and Matthias Egger and Farhat, {Maha R.} and Lanfranco Fattorini and Iris Finci and {Le Ray}, {Laure Fournier} and Victoria Furio and Ramona Groenheit and Tawanda Gumbo and Heysell, {Scott K.} and Doris Hillemann and Harald Hoffmann and Po-Ren Hsueh and Yi Hu and Hairong Huang and Alamdar Hussain and Farzana Ismail and Kiyohiko Izumi and Tomasz Jagielski and Leen Rigouts and Sarah Sengstake and Gabriela Torrea and {Van Deun}, Armand",

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doi = "10.1183/13993003.00166-2022",

language = "English",

volume = "59",

journal = "European Respiratory Journal",

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AU - Antimycobacterial Susceptibility T

AU - Georghiou, Sophia B.

AU - Rodwell, Timothy C.

AU - Korobitsyn, Alexei

AU - Abbadi, Said H.

AU - Ajbani, Kanchan

AU - Alffenaar, Jan-Willem

AU - Alland, David

AU - Alvarez, Nataly

AU - Andres, Sonke

AU - Ardizzoni, Elisa

AU - Aubry, Alexandra

AU - Baldan, Rossella

AU - Ballif, Marie

AU - Barilar, Ivan

AU - Bottger, Erik C.

AU - Chakravorty, Soumitesh

AU - Claxton, Pauline M.

AU - Cirillo, Daniela M.

AU - Comas, Inaki

AU - Coulter, Chris

AU - Denkinger, Claudia M.

AU - Derendinger, Brigitta

AU - Desmond, Edward P.

AU - de Steenwinkel, Jurriaan E. M.

AU - Dheda, Keertan

AU - Diacon, Andreas H.

AU - Dolinger, David L.

AU - Dooley, Kelly E.

AU - Egger, Matthias

AU - Farhat, Maha R.

AU - Fattorini, Lanfranco

AU - Finci, Iris

AU - Le Ray, Laure Fournier

AU - Furio, Victoria

AU - Groenheit, Ramona

AU - Gumbo, Tawanda

AU - Heysell, Scott K.

AU - Hillemann, Doris

AU - Hoffmann, Harald

AU - Hsueh, Po-Ren

AU - Hu, Yi

AU - Huang, Hairong

AU - Hussain, Alamdar

AU - Ismail, Farzana

AU - Izumi, Kiyohiko

AU - Jagielski, Tomasz

AU - Rigouts, Leen

AU - Sengstake, Sarah

AU - Torrea, Gabriela

AU - Van Deun, Armand

N1 - FTX; (CC BY 4.0)

PY - 2022

Y1 - 2022

N2 - Inappropriately high breakpoints have resulted in systematic false-susceptible AST results to anti-TB drugs. MIC, PK/PD and clinical outcome data should be combined when setting breakpoints to minimise the emergence and spread of antimicrobial resistance. https://bit.ly/3i43wb6

AB - Inappropriately high breakpoints have resulted in systematic false-susceptible AST results to anti-TB drugs. MIC, PK/PD and clinical outcome data should be combined when setting breakpoints to minimise the emergence and spread of antimicrobial resistance. https://bit.ly/3i43wb6

KW - Antitubercular Agents/pharmacology

KW - Drug Resistance, Bacterial

KW - Drug Resistance, Multiple, Bacterial

KW - Humans

KW - Microbial Sensitivity Tests

KW - Mycobacterium tuberculosis

KW - Tuberculosis, Multidrug-Resistant/diagnosis

U2 - 10.1183/13993003.00166-2022

DO - 10.1183/13993003.00166-2022

M3 - A1: Web of Science-article

C2 - 35422426

SN - 0903-1936

VL - 59

JO - European Respiratory Journal

JF - European Respiratory Journal

IS - 4

M1 - 2200166

ER -

Updating the approaches to define susceptibility and resistance to anti-tuberculosis agents: implications for diagnosis and treatment

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Keywords

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