Variant analysis of SARS-CoV-2 genomes from Belgian military personnel engaged in overseas missions and operations

Jean-Paul Pirnay, Philippe Selhorst, Samuel L. Hong, Christel Cochez, Barney Potter, Piet Maes, Mauro Petrillo, Gytis Dudas, Vincent Claes, Yolien Van der Beken, Gilbert Verbeken, Julie Degueldre, Simon Dellicour, Lize Cuypers, France T'Sas, Guy Van den Eede, Bruno Verhasselt, Wouter Weuts, Cedric Smets, Jan MertensPhilippe Geeraerts, Kevin K. Ariën, Emmanuel Andre, Pierre Neirinckx, Patrick Soentjens, Guy Baele

Research output: Contribution to journalA1: Web of Science-article

Abstract

More than a year after the first identification of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as the causative agent of the 2019 coronavirus disease (COVID-19) in China, the emergence and spread of genomic variants of this virus through travel raise concerns regarding the introduction of lineages in previously unaffected regions, requiring adequate containment strategies. Concomitantly, such introductions fuel worries about a possible increase in transmissibility and disease severity, as well as a possible decrease in vaccine efficacy. Military personnel are frequently deployed on missions around the world. As part of a COVID-19 risk mitigation strategy, Belgian Armed Forces that engaged in missions and operations abroad were screened (7683 RT-qPCR tests), pre- and post-mission, for the presence of SARS-CoV-2, including the identification of viral lineages. Nine distinct viral genotypes were identified in soldiers returning from operations in Niger, the Democratic Republic of the Congo, Afghanistan, and Mali. The SARS-CoV-2 variants belonged to major clades 19B, 20A, and 20B (Nextstrain nomenclature), and included "variant of interest" B.1.525, "variant under monitoring" A.27, as well as lineages B.1.214, B.1, B.1.1.254, and A (pangolin nomenclature), some of which are internationally monitored due to the specific mutations they harbor. Through contact tracing and phylogenetic analysis, we show that isolation and testing policies implemented by the Belgian military command appear to have been successful in containing the influx and transmission of these distinct SARS-CoV-2 variants into military and civilian populations.

Original languageEnglish
Article number1359
JournalViruses-Basel
Volume13
Issue number7
Number of pages19
ISSN1999-4915
DOIs
Publication statusPublished - 2021

Keywords

  • SARS-CoV-2
  • COVID-19
  • military
  • outbreak
  • variants
  • genomic epidemiology

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