Variation in antiretroviral treatment coverage and virological suppression among three HIV key populations

EuroSIDA Study Grp

Research output: Contribution to journalA1: Web of Science-article

Abstract

Objectives: We assessed differences in antiretroviral treatment (ART) coverage and virological suppression across three HIV key populations, as defined by self-reported HIV transmission category: sex between men, injection drug use (IDU) and heterosexual transmission.

Design: A multinational cohort study.

Methods: Within the EuroSIDA study, we assessed region-specific percentages of ART coverage among those in care and virological suppression (

Results: Among 12 872 participants followed from 1 July 2014 to 30 June 2016, the percentages of ART-coverage and virological suppression varied between transmission categories, depending on geographical region (global P for interaction: P = 0.0148 for ART-coverage, P = 0.0006 for virological suppression). In Western [adjusted odds ratio (aOR) 1.41 (95% confidence interval 1.14-1.75)] and Northern Europe [aOR 1.68 (95% confidence interval 1.25-2.26)], heterosexuals were more likely to receive ART than MSM, while in Eastern Europe, there was some evidence that infection through IDU [aOR 0.60 (95% confidence interval 0.31-1.14)] or heterosexual contact [aOR 0.58 (95% confidence interval 0.30-1.10)] was associated with lower odds of receiving ART. In terms of virological suppression, people infected through IDU or heterosexual contact in East Central and Eastern Europe were around half as likely as MSM to have a suppressed viral load on ART, while we observed no differences in virological suppression across transmission categories in Western and Northern Europe.

Conclusion: In our cohort, patterns of ART-coverage and virological suppression among key populations varied by geographical region, emphasizing the importance of tailoring HIV programmes to the local epidemic. Copyright (C) 2018 Wolters Kluwer Health, Inc. All rights reserved.

Original languageEnglish
JournalAIDS
Volume32
Issue number18
Pages (from-to)2807-2819
Number of pages13
ISSN0269-9370
DOIs
Publication statusPublished - 2018

Keywords

  • antiretroviral therapy
  • HIV
  • HIV care continuum
  • key and vulnerable populations
  • public health
  • viral suppression
  • INJECTING DRUG-USERS
  • HEPATITIS-C VIRUS
  • EASTERN-EUROPE
  • CARE
  • INFECTION
  • CASCADE
  • SEX
  • CONTINUUM
  • BARRIERS
  • RUSSIA

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