Variation in fasting and non-fasting serum enterolactone concentrations in women of the Malmo Diet and Cancer cohort

E. Sonestedt; U. Ericson; B. Gullberg; J. L. Penalvo; H. Adlercreutz; E. Wirfalt

doi:10.1038/sj.ejcn.1602811

Variation in fasting and non-fasting serum enterolactone concentrations in women of the Malmo Diet and Cancer cohort

E. Sonestedt, U. Ericson, B. Gullberg, J. L. Penalvo, H. Adlercreutz, E. Wirfalt

Research output: Contribution to journal › A1: Web of Science-article › peer-review

Abstract

Objectives: The aim of this study was to examine the variation of enterolactone from fasting and non-fasting blood of middle-aged healthy women eating a normal diet to determine the usefulness of a single sample in epidemiological studies.

Subjects and methods: Twenty-six women born between 1940 and 1950 were recruited within the Malmo Diet and Cancer cohort. Three non-fasting and two overnight fasting samples were collected from each individual during a 5-week period. Twenty-one participated in all measurements. Enterolactone concentrations were analyzed by time-resolved fluoroimmunoassay.

Results: The within-subject and between-subject variations (coefficient of variations, CV) were estimated to 59 and 89% respectively for fasting samples and 71 and 67% for non-fasting samples. The intraclass correlation coefficients (ICC) were estimated to 0.66 (95% confidence interval (CI) 0.35-0.84) for fasting and 0.48 ( 95% CI, 0.22-0.72) for non-fasting samples.

Conclusions: Although the estimated ICC for blood samples was moderate, it indicates that enterolactone levels of both fasting and non-fasting blood samples should be useful in future projects within the Malmo Diet and Cancer cohort.

Original language	English
Journal	European Journal of Clinical Nutrition
Volume	62
Issue number	8
Pages (from-to)	1005-1009
Number of pages	5
ISSN	0954-3007
DOIs	https://doi.org/10.1038/sj.ejcn.1602811
Publication status	Published - Aug-2008
Externally published	Yes

Keywords

enterolactone
serum
lignans
biomarker
time-resolved fluoroimmunoassay
TIME-RESOLVED FLUOROIMMUNOASSAY
PLASMA ENTEROLACTONE
POSTMENOPAUSAL WOMEN
MEASUREMENT ERROR
LIGNANS
METABOLISM
PERIOD
RISK
REPRODUCIBILITY
PHYTOESTROGENS

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title = "Variation in fasting and non-fasting serum enterolactone concentrations in women of the Malmo Diet and Cancer cohort",

abstract = "Objectives: The aim of this study was to examine the variation of enterolactone from fasting and non-fasting blood of middle-aged healthy women eating a normal diet to determine the usefulness of a single sample in epidemiological studies.Subjects and methods: Twenty-six women born between 1940 and 1950 were recruited within the Malmo Diet and Cancer cohort. Three non-fasting and two overnight fasting samples were collected from each individual during a 5-week period. Twenty-one participated in all measurements. Enterolactone concentrations were analyzed by time-resolved fluoroimmunoassay.Results: The within-subject and between-subject variations (coefficient of variations, CV) were estimated to 59 and 89% respectively for fasting samples and 71 and 67% for non-fasting samples. The intraclass correlation coefficients (ICC) were estimated to 0.66 (95% confidence interval (CI) 0.35-0.84) for fasting and 0.48 ( 95% CI, 0.22-0.72) for non-fasting samples.Conclusions: Although the estimated ICC for blood samples was moderate, it indicates that enterolactone levels of both fasting and non-fasting blood samples should be useful in future projects within the Malmo Diet and Cancer cohort.",

keywords = "enterolactone, serum, lignans, biomarker, time-resolved fluoroimmunoassay, TIME-RESOLVED FLUOROIMMUNOASSAY, PLASMA ENTEROLACTONE, POSTMENOPAUSAL WOMEN, MEASUREMENT ERROR, LIGNANS, METABOLISM, PERIOD, RISK, REPRODUCIBILITY, PHYTOESTROGENS",

author = "E. Sonestedt and U. Ericson and B. Gullberg and Penalvo, {J. L.} and H. Adlercreutz and E. Wirfalt",

year = "2008",

month = aug,

doi = "10.1038/sj.ejcn.1602811",

language = "English",

volume = "62",

pages = "1005--1009",

journal = "European Journal of Clinical Nutrition",

issn = "0954-3007",

publisher = "Nature Publishing Group",

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T1 - Variation in fasting and non-fasting serum enterolactone concentrations in women of the Malmo Diet and Cancer cohort

AU - Sonestedt, E.

AU - Ericson, U.

AU - Gullberg, B.

AU - Penalvo, J. L.

AU - Adlercreutz, H.

AU - Wirfalt, E.

PY - 2008/8

Y1 - 2008/8

N2 - Objectives: The aim of this study was to examine the variation of enterolactone from fasting and non-fasting blood of middle-aged healthy women eating a normal diet to determine the usefulness of a single sample in epidemiological studies.Subjects and methods: Twenty-six women born between 1940 and 1950 were recruited within the Malmo Diet and Cancer cohort. Three non-fasting and two overnight fasting samples were collected from each individual during a 5-week period. Twenty-one participated in all measurements. Enterolactone concentrations were analyzed by time-resolved fluoroimmunoassay.Results: The within-subject and between-subject variations (coefficient of variations, CV) were estimated to 59 and 89% respectively for fasting samples and 71 and 67% for non-fasting samples. The intraclass correlation coefficients (ICC) were estimated to 0.66 (95% confidence interval (CI) 0.35-0.84) for fasting and 0.48 ( 95% CI, 0.22-0.72) for non-fasting samples.Conclusions: Although the estimated ICC for blood samples was moderate, it indicates that enterolactone levels of both fasting and non-fasting blood samples should be useful in future projects within the Malmo Diet and Cancer cohort.

AB - Objectives: The aim of this study was to examine the variation of enterolactone from fasting and non-fasting blood of middle-aged healthy women eating a normal diet to determine the usefulness of a single sample in epidemiological studies.Subjects and methods: Twenty-six women born between 1940 and 1950 were recruited within the Malmo Diet and Cancer cohort. Three non-fasting and two overnight fasting samples were collected from each individual during a 5-week period. Twenty-one participated in all measurements. Enterolactone concentrations were analyzed by time-resolved fluoroimmunoassay.Results: The within-subject and between-subject variations (coefficient of variations, CV) were estimated to 59 and 89% respectively for fasting samples and 71 and 67% for non-fasting samples. The intraclass correlation coefficients (ICC) were estimated to 0.66 (95% confidence interval (CI) 0.35-0.84) for fasting and 0.48 ( 95% CI, 0.22-0.72) for non-fasting samples.Conclusions: Although the estimated ICC for blood samples was moderate, it indicates that enterolactone levels of both fasting and non-fasting blood samples should be useful in future projects within the Malmo Diet and Cancer cohort.

KW - enterolactone

KW - serum

KW - lignans

KW - biomarker

KW - time-resolved fluoroimmunoassay

KW - TIME-RESOLVED FLUOROIMMUNOASSAY

KW - PLASMA ENTEROLACTONE

KW - POSTMENOPAUSAL WOMEN

KW - MEASUREMENT ERROR

KW - LIGNANS

KW - METABOLISM

KW - PERIOD

KW - RISK

KW - REPRODUCIBILITY

KW - PHYTOESTROGENS

U2 - 10.1038/sj.ejcn.1602811

DO - 10.1038/sj.ejcn.1602811

M3 - A1: Web of Science-article

SN - 0954-3007

VL - 62

SP - 1005

EP - 1009

JO - European Journal of Clinical Nutrition

JF - European Journal of Clinical Nutrition

IS - 8

ER -

Variation in fasting and non-fasting serum enterolactone concentrations in women of the Malmo Diet and Cancer cohort

Abstract

Keywords

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