TY - JOUR
T1 - What Is the added benefit of oropharyngeal swabs compared to nasal swabs alone for respiratory virus detection in hospitalized children aged
AU - Dawood, Fatimah S
AU - Jara, Jorge
AU - Estripeaut, Dora
AU - Vergara, Ofelina
AU - Luciani, Kathia
AU - Corro, Mary
AU - de León, Tirza
AU - Saldaña, Ricardo
AU - Castillo Baires, Juan Miguel
AU - Rauda Flores, Rafael
AU - Cazares, Rafael A
AU - Brizuela de Fuentes, Yarisa Sujey
AU - Franco, Danilo
AU - Gaitan, Melissa
AU - Schneider, Eileen
AU - Berman, LaShondra
AU - Azziz-Baumgartner, Eduardo
AU - Widdowson, Marc-Alain
N1 - PPU; Published by Oxford University Press on behalf of the Infectious Diseases Society of America 2015. This work is written by (a) US Government employee(s) and is in the public domain in the US.
PY - 2015
Y1 - 2015
N2 - We evaluated the added value of collecting both nasal and oropharyngeal swabs, compared with collection of nasal swabs alone, for detection of common respiratory viruses by reverse transcription-polymerase chain reaction in hospitalized children aged <10 years. Nasal swabs had equal or greater sensitivity than oropharyngeal swabs for detection of respiratory syncytial virus, adenovirus, human metapneumovirus, rhinovirus, and influenza virus but not parainfluenza virus. The addition of an oropharyngeal swab, compared with use of a nasal swab alone, increased the frequency of detection of each respiratory virus by no more than 10% in children aged <10 years.
AB - We evaluated the added value of collecting both nasal and oropharyngeal swabs, compared with collection of nasal swabs alone, for detection of common respiratory viruses by reverse transcription-polymerase chain reaction in hospitalized children aged <10 years. Nasal swabs had equal or greater sensitivity than oropharyngeal swabs for detection of respiratory syncytial virus, adenovirus, human metapneumovirus, rhinovirus, and influenza virus but not parainfluenza virus. The addition of an oropharyngeal swab, compared with use of a nasal swab alone, increased the frequency of detection of each respiratory virus by no more than 10% in children aged <10 years.
KW - Child
KW - Child, Hospitalized
KW - Child, Preschool
KW - Humans
KW - Infant
KW - Infant, Newborn
KW - Molecular Diagnostic Techniques
KW - Mouth/virology
KW - Nasal Cavity/virology
KW - Prospective Studies
KW - Respiratory Tract Infections/diagnosis
KW - Reverse Transcriptase Polymerase Chain Reaction
KW - Sensitivity and Specificity
KW - Specimen Handling/methods
KW - Virus Diseases/diagnosis
KW - Viruses/isolation & purification
U2 - 10.1093/infdis/jiv265
DO - 10.1093/infdis/jiv265
M3 - A1: Web of Science-article
C2 - 25943205
SN - 0022-1899
VL - 212
SP - 1600
EP - 1603
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 10
ER -