• Nationalestraat 155

    2000 Antwerpen

    België

Vind ons hier

Organisatieprofiel

Organisatie profiel

Introduction

In the Unit of Molecular Parasitology, the focus lays on Leishmania, with a particular attention on drug-resistance and associated phenotypes (drug resistant parasites are also more virulent). Genomics and metabolomics are running since 4 years and we now enter the phase of functional testing of the importance of gene dosage in the survival skills of the parasite; integration in a true systems biology approach (through the addition of transcriptomic and proteomic layers) is considered. We also aim to develop methods allowing direct whole genome sequencing in (sub)clinical samples as well as single cell genomics.

Jean-Claude Dujardin is the head of the Unit of Molecular Parasitology since 2002.

Main activities

  • Drug resistance in leishmaniasis: mechanisms, link with survival skills, in vitro and in vivo phenotyping, experimental validation, surveillance tools, interacting closely with ‘clinomics’ line; our expertise in drug resistance is also used to support R&D for new antileishmania drugs
  • ‘Clinomic’ diversity in leishmania: genomic, transcriptomic, metabolomic exploitation of parasite collections linked to well-documented cohorts of patients (understanding of clinical and in vitro/vivo phenotypic diversity, parasite evolution)
  • Molecular epidemiology of leishmaniasis: (i) further dissemination of standardized and QA-typing tests and (ii) application of molecular tools for characterization of transmission patterns (with a special interest for asymptomatic infections)

Vingerafdruk

Duik in de onderzoeksonderwerpen waar Moleculaire Parasitologie actief is. Deze onderwerplabels zijn gebaseerd op het werk van de leden van deze organisatie. Samen vormen ze een unieke vingerafdruk.

Netwerk

Recente externe samenwerking op landniveau. Duik in de details door op de punten te klikken.
  • A community resource for paired genomic and metabolomic data mining

    Schorn, M. A., Verhoeven, S., Ridder, L., Huber, F., Acharya, D. D., Aksenov, A. A., Aleti, G., Moghaddam, J. A., Aron, A. T., Aziz, S., Bauermeister, A., Bauman, K. D., Baunach, M., Beemelmanns, C., Beman, J. M., Berlanga-Clavero, M. V., Blacutt, A. A., Bode, H. B., Boullie, A., Brejnrod, A. & 90 anderen, Bugni, T. S., Calteau, A., Cao, L., Carrión, V. J., Castelo-Branco, R., Chanana, S., Chase, A. B., Chevrette, M. G., Costa-Lotufo, L. V., Crawford, J. M., Currie, C. R., Cuypers, B., Dang, T., de Rond, T., Demko, A. M., Dittmann, E., Du, C., Drozd, C., Dujardin, J-C., Dutton, R. J., Edlund, A., Fewer, D. P., Garg, N., Gauglitz, J. M., Gentry, E. C., Gerwick, L., Glukhov, E., Gross, H., Gugger, M., Guillén Matus, D. G., Helfrich, E. J. N., Hempel, B-F., Hur, J-S., Iorio, M., Jensen, P. R., Kang, K. B., Kaysser, L., Kelleher, N. L., Kim, C. S., Kim, K. H., Koester, I., König, G. M., Leao, T., Lee, S. R., Lee, Y-Y., Li, X., Little, J. C., Maloney, K. N., Männle, D., Martin H, C., McAvoy, A. C., Metcalf, W. W., Mohimani, H., Molina-Santiago, C., Moore, B. S., Mullowney, M. W., Muskat, M., Nothias, L-F., O'Neill, E. C., Parkinson, E. I., Petras, D., Piel, J., Pierce, E. C., Pires, K., Reher, R., Romero, D., Roper, M. C., Rust, M., Saad, H., Saenz, C., Sanchez, L. M., Sørensen, S. J., Sosio, M., Süssmuth, R. D., Sweeney, D., Tahlan, K., Thomson, R. J., Tobias, N. J., Trindade-Silva, A. E., van Wezel, G. P., Wang, M., Weldon, K. C., Zhang, F., Ziemert, N., Duncan, K. R., Crüsemann, M., Rogers, S., Dorrestein, P. C., Medema, M. H. & van der Hooft, J. J. J., 2021, In : Nature Chemical Biology. 17, 4, blz. 363-368 6 blz.

    Onderzoeksoutput: Bijdrage aan tijdschriftCommentaar/debat

  • Assessing L. donovani skin parasite load: a proof of concept study of a microbiopsy device in an Indian setting

    Cloots, K., Singh, O. P., Singh, A. K., Van der Auwera, G., Kumar, P., Gedda, M. R., Rai, T. K., Hasker, E., Sundar, S. & Boelaert, M., 2021, In : Frontiers in Cellular and Infection Microbiology. 11, 9 blz., 645121.

    Onderzoeksoutput: Bijdrage aan tijdschriftA1: Web of Science-artikel

    Open Access
    Bestand
    1 Downloads (Pure)
  • HLA-DRB1 alleles associated with lower leishmaniasis susceptibility share common amino acid polymorphisms and epitope binding repertoires

    de Vrij, N., Meysman, P., Gielis, S., Adriaensen, W., Laukens, K. & Cuypers, B., 2021, In : Vaccines. 9, 3, 17 blz., 270.

    Onderzoeksoutput: Bijdrage aan tijdschriftA1: Web of Science-artikel

    Open Access
    Bestand