Chlamydia trachomatis test-of-cure cannot be based on a single highly sensitive laboratory test taken at least 3 weeks after treatment

Nicole H T M Dukers-Muijrers, Servaas A Morré, Arjen Speksnijder, Marianne A B van der Sande, Christian J P A Hoebe

Onderzoeksoutput: Bijdrage aan tijdschriftArtikel

Uittreksel

Current test-of-cure practice in patients with Chlamydia trachomatis (Ct) infection is to confirm cure with a single test taken at least 3 weeks after treatment. Effectiveness of single-time-point testing however lacks a scientific evidence basis and the high sensitivity of laboratory assays nowadays in use for this purpose may compromise the clinical significance of their results. Prospectively following 59 treated Ct infections, administering care as usual, the presence of Ct plasmid DNA and rRNA was systematically assessed by multiple time-sequential measurements, i.e. on 18 samples taken per patient during 8 weeks following treatment with a single dose of 1000 mg Azythromycin. A high proportion (42%) of Ct infections tested positive on at least one of the samples taken after 3 weeks. Patients' test results showed substantial inter-individual and intra-individual variation over time and by type of NAAT used. We demonstrated frequent intermittent positive patterns in Ct test results over time, and strongly argue against current test-of-cure practice.

TaalEngels
TijdschriftPLoS ONE
Volume7
Exemplaarnummer3
Pagina's (van-tot)e34108
ISSN1932-6203
DOI's
StatusGepubliceerd - 2012

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