Karyotype polymorphism and conserved characters in the Leishmania (viannia) braziliensis complex explored with chromosome-derived probes

JC Dujardin, N Gajendran, J Arevalo, A Llanos-Cuentas, H Guerra, J Gomez, J Arroyo, S De Doncker, D Jacquet, R Hamers, D Le Ray

Onderzoeksoutput: Bijdrage aan tijdschriftA1: Web of Science-artikel

Uittreksel

Molecular karyotype of 45 reference populations of Neotropical leishmanias was analyzed with ethidium bromide staining and with 6 chromosome-derived probes selected from a genomic library of Leishmania (Viannia) braziliensis. Size-conserved patterns were identified and found to be specific to subgenus Viannia and to its constitutive species. An important issue for epidemiology and clinical investigations was the discrimination between L. (V.) peruviana and L. (V.) braziliensis, 2 species found very similar by other genetic techniques, but responsible for totally different clinical patterns. The suggested existence of genetically distinct demes, or karyodemes, within the group-species might also show to be of importance, as these populations might differ in virulence, host-specificity and clinical manifestations
TaalEngels
TijdschriftAnnales de la Société Belge de Médecine Tropicale
Volume73
Pagina's (van-tot)101-118
ISSN0365-6527
StatusGepubliceerd - 1993

Trefwoorden

  • B780-tropische-geneeskunde

Vingerafdruk Bekijk de onderzoeksthema's van 'Karyotype polymorphism and conserved characters in the Leishmania (viannia) braziliensis complex explored with chromosome-derived probes'. Samen vormen ze een unieke vingerafdruk.

Dit citeren