M48U1 CD4 mimetic has a sustained inhibitory effect on cell-associated HIV-1 by attenuating virion infectivity through gp120 shedding

P. Selhorst, K. Grupping, T. Tong, E.T. Crooks, L. Martin, G. Vanham, J.M. Binley, K.K. Ariën

Onderzoeksoutput: Bijdrage aan tijdschriftA1: Web of Science-artikel

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BACKGROUND: HIV-1 infected cells can establish new infections by crossing the vaginal epithelia and subsequently producing virus in a milieu that avoids the high microbicide concentrations of the vaginal lumen. FINDINGS: To address this problem, here, we report that pretreatment of HIV-infected peripheral blood mononuclear cells (PBMCs) with a 27 amino acid CD4-mimetic, M48U1, causes dramatic and prolonged reduction of infectious virus output, due to its induction of gp120 shedding. CONCLUSIONS: M48U1 may, therefore, be valuable for prophylaxis of mucosal HIV-1 transmission.
TaalEngels
TijdschriftRetrovirology
Volume10
Exemplaarnummer12
Pagina's (van-tot)1-9
Aantal pagina's9
ISSN1742-4690
DOI's
StatusGepubliceerd - 2013

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